Wang Zhihua, Li Xiaoqing, Li Dan, Li Yahong
The Fourth Department of Infectious Diseases, Xi'an Children's Hospital Affiliated with the School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Turk J Pediatr. 2012 Mar-Apr;54(2):99-104.
Since its first recognition, the 2009 pandemic influenza A (H1N1) virus rapidly spread worldwide. We observed the clinical characteristics of 167 hospitalized patients who were confirmed by testing pharyngeal or nasopharyngeal swabs with the use of a real-time reverse-transcriptase polymerase chain reaction (RT-PCR) assay. The mean age of the 167 hospitalized patients was 4.1 years, and 58.7% were male. The most common symptoms and signs were fever (91.6%), cough (82.6%), pharyngeal congestion (95.2%), and swollen tonsils (34.1%). The major complications were bronchitis (19.2%), bronchial pneumonia (10.8%), neutropenia (49.7%), and leukopenia (38.9%). The duration of hospitalization, fever and the course of disease in the patients who were treated with oseltamivir were shorter than in those who were treated with ribavirin. All of the patients fully recuperated from the 2009 epidemic influenza A (H1N1) infection with one exception.
自首次被发现以来，2009年甲型H1N1流感大流行病毒迅速在全球传播。我们观察了167例住院患者的临床特征，这些患者通过使用实时逆转录聚合酶链反应（RT-PCR）检测咽拭子或鼻咽拭子得以确诊。167例住院患者的平均年龄为4.1岁，男性占58.7%。最常见的症状和体征为发热（91.6%）、咳嗽（82.6%）、咽部充血（95.2%）和扁桃体肿大（34.1%）。主要并发症为支气管炎（19.2%）、支气管肺炎（10.8%）、中性粒细胞减少（49.7%）和白细胞减少（38.9%）。接受奥司他韦治疗的患者的住院时间、发热时间和病程比接受利巴韦林治疗的患者短。除1例患者外，所有患者均从2009年甲型H1N1流感感染中完全康复。
