Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan.
Clin Drug Investig. 2012 Aug 1;32(8):547-53. doi: 10.1007/BF03261908.
We report on the case of a severely osteoporotic elderly Japanese woman with bisphosphonate-associated osteonecrosis of the jaw (ONJ), who was treated successfully with teriparatide. A 79-year-old woman with severe osteoporosis and bisphosphonate-associated ONJ was treated with teriparatide after debridement of the necrotic tissue in the jaw bone. Computed tomography (CT) images revealed the bone defect in the mandible after debridement of the necrotic tissue associated with ONJ. According to the attending dentist, the ONJ healed after 2 months of therapy. After 3 months of treatment, a robust increase in the serum level of the bone formation marker, serum intact procollagen type 1 N-terminal propeptide, was noted and a repeat CT revealed improvement of the bone defect of the mandible. These results suggest the beneficial effects of teriparatide therapy in the severely osteoporotic elderly woman with ONJ.
我们报告了一例严重骨质疏松的老年日本女性，她患有与双膦酸盐相关的下颌骨骨坏死（ONJ），经特立帕肽治疗后成功治愈。一位 79 岁的严重骨质疏松症和与双膦酸盐相关的 ONJ 患者，在颌骨坏死组织清创后接受了特立帕肽治疗。计算机断层扫描（CT）图像显示，在与 ONJ 相关的坏死组织清创后，下颌骨存在骨缺损。根据主治牙医的说法，ONJ 在治疗 2 个月后愈合。治疗 3 个月后，血清骨形成标志物血清完整原胶原型 1 N 端前肽水平显著升高，重复 CT 显示下颌骨骨缺损得到改善。这些结果表明特立帕肽治疗对患有 ONJ 的严重骨质疏松老年女性具有有益作用。
