Sakkas L I, Loqueman N, Bird H, Vaughan R W, Welsh K I, Panayi G S
Division of Medicine, UMDS, Guy's Hospital, London, UK.
J Rheumatol. 1990 Nov;17(11):1487-90.
HLA-DRB, DQA and DQB genes as well as the T cell receptor (TcR) alpha, beta, and gamma genes were studied by Southern blot analysis of genomic DNA from patients with psoriatic arthritis (PsA) and psoriasis alone (Ps). A subtype of DR7, DR7a, was found in 38.8% of patients with PsA, 41.5% of patients with Ps, and in 8% of healthy individuals (N) (PsA vs N: pc = 0.0002, RR = 7.1; Ps vs N: pc = 0.0002, RR = 7.9). No association with TcR genes was found. Our findings suggest either that the DR7a allele may be in linkage disequilibrium with HLA-Cw6 or that it may be an important susceptibility factor for PsA and Ps.
通过对银屑病关节炎（PsA）患者及单纯银屑病（Ps）患者的基因组DNA进行Southern印迹分析，研究了HLA - DRB、DQA和DQB基因以及T细胞受体（TcR）α、β和γ基因。在38.8%的PsA患者、41.5%的Ps患者以及8%的健康个体（N）中发现了DR7的一个亚型DR7a（PsA与N相比：pc = 0.0002，RR = 7.1；Ps与N相比：pc = 0.0002，RR = 7.9）。未发现与TcR基因有关联。我们的研究结果表明，要么DR7a等位基因可能与HLA - Cw6处于连锁不平衡状态，要么它可能是PsA和Ps的一个重要易感因素。
