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Understanding the role of PNPLA3 genetic variants in patients with chronic hepatitis C infection.

作者信息

Aghemo Alessio

出版信息

Dig Dis Sci. 2012 Aug;57(8):1977-9. doi: 10.1007/s10620-012-2277-2. Epub 2012 Jun 27.

DOI:10.1007/s10620-012-2277-2
PMID:22736017
Abstract
摘要

相似文献

1
Understanding the role of PNPLA3 genetic variants in patients with chronic hepatitis C infection.了解PNPLA3基因变异在慢性丙型肝炎感染患者中的作用。
Dig Dis Sci. 2012 Aug;57(8):1977-9. doi: 10.1007/s10620-012-2277-2. Epub 2012 Jun 27.
2
Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C.腹部脂肪与 PNPLA3 I148M 相互作用,但与慢性丙型肝炎肝脂肪变性发病机制中的 APOC3 变异体无关。
J Viral Hepat. 2013 Aug;20(8):517-23. doi: 10.1111/jvh.12053. Epub 2013 Jan 7.
3
No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis.
Infez Med. 2018 Sep 1;26(3):244-248.
4
Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C.PNPLA3基因分型对慢性丙型肝炎进展具有独特的酒精调节作用。
J Hepatol. 2011 Sep;55(3):732-733. doi: 10.1016/j.jhep.2011.01.025. Epub 2011 Feb 11.
5
Impact of PNPLA3 variants on liver histology of 168 patients with HIV infection and chronic hepatitis C.PNPLA3 变异对 168 例 HIV 感染合并慢性丙型肝炎患者肝组织学的影响。
Clin Microbiol Infect. 2016 Apr;22(4):372-378. doi: 10.1016/j.cmi.2015.11.025. Epub 2016 Jan 20.
6
Modulation of the effect of PNPLA3 I148M mutation on steatosis and liver damage by alcohol intake in patients with chronic hepatitis C.慢性丙型肝炎患者饮酒对PNPLA3 I148M突变所致脂肪变性和肝损伤影响的调节作用
J Hepatol. 2011 Dec;55(6):1470-1; author reply 1471-2. doi: 10.1016/j.jhep.2011.04.032.
7
The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.PNPLA3基因的rs738409多态性与巴西慢性丙型肝炎患者的肝脂肪变性和肝纤维化相关。
BMC Infect Dis. 2017 Dec 19;17(1):780. doi: 10.1186/s12879-017-2887-6.
8
Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection.糖尿病和 PNPLA3 基因变异与慢性丙型肝炎病毒感染患者疾病严重程度的关联。
J Hepatol. 2015 Mar;62(3):512-8. doi: 10.1016/j.jhep.2014.10.011. Epub 2014 Oct 20.
9
Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C.PNPLA3基因rs738409变异体(I148M)对日本慢性丙型肝炎患者肝脂肪变性、坏死性炎症及肝纤维化的影响
J Gastroenterol. 2015 Aug;50(8):887-93. doi: 10.1007/s00535-014-1018-z. Epub 2014 Nov 26.
10
Impact of patatin-like phospholipase domain containing 3 rs738409 G/G genotype on hepatic decompensation and mortality in patients with portal hypertension.载脂蛋白样磷脂酶域包含 3 号 rs738409 G/G 基因型对门脉高压患者肝失代偿和死亡率的影响。
Aliment Pharmacol Ther. 2018 Aug;48(4):451-459. doi: 10.1111/apt.14856. Epub 2018 Jun 29.

引用本文的文献

1
Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation.PNPLA3 I148M变异与慢性病毒性肝炎、自身免疫性肝病及肝移植结局的关联
Hepat Mon. 2015 Apr 25;15(4):e26459. doi: 10.5812/hepatmon.15(4)2015.26459. eCollection 2015 Apr.

本文引用的文献

1
Assessing long-term treatment efficacy in chronic hepatitis B and C: between evidence and common sense.评估慢性乙型肝炎和丙型肝炎的长期治疗效果:证据与常识之间。
J Hepatol. 2012 Dec;57(6):1326-35. doi: 10.1016/j.jhep.2012.06.025. Epub 2012 Jun 28.
2
The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.遗传变异与基因型 1 慢性丙型肝炎感染患者肝脂肪变性的相关性。
Dig Dis Sci. 2012 Aug;57(8):2213-21. doi: 10.1007/s10620-012-2171-y. Epub 2012 Apr 29.
3
Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin.
载脂蛋白基因多态性对聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎患者的影响。
Aliment Pharmacol Ther. 2012 Jun;35(12):1434-42. doi: 10.1111/j.1365-2036.2012.05109.x. Epub 2012 Apr 24.
4
Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients.慢性丙型肝炎非3型患者中,IL28B与PNPLA3基因分型在脂肪变性发病机制中的相互作用。
J Hepatol. 2012 May;56(5):1209-1210. doi: 10.1016/j.jhep.2011.10.024. Epub 2012 Jan 8.
5
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases.1型慢性丙型肝炎病毒感染治疗的最新进展:美国肝病研究协会2011年实践指南
Hepatology. 2011 Oct;54(4):1433-44. doi: 10.1002/hep.24641. Epub 2011 Sep 26.
6
Hyporesponsiveness to PegIFNα2B plus ribavirin in patients with hepatitis C-related advanced fibrosis.对丙型肝炎相关晚期纤维化患者使用聚乙二醇干扰素 α2B 加利巴韦林的低反应性。
J Hepatol. 2012 Feb;56(2):341-7. doi: 10.1016/j.jhep.2011.05.022. Epub 2011 Jul 12.
7
Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.携带 IL28B 有利基因型的慢性丙型肝炎患者肝脂肪变性频率较低。
J Hepatol. 2011 Dec;55(6):1195-200. doi: 10.1016/j.jhep.2011.03.015. Epub 2011 Apr 14.
8
Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.载脂蛋白样磷脂酶 3(rs738409 C>G)多态性对慢性丙型肝炎纤维化进展和脂肪变性的影响。
Hepatology. 2011 Jul;54(1):60-9. doi: 10.1002/hep.24350.
9
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.PNPLA3 基因 patatin 样磷脂酶结构域包含 3 基因(PNPLA3)I148M 变体对非酒精性脂肪性肝病易感性和组织学严重程度影响的荟萃分析。
Hepatology. 2011 Jun;53(6):1883-94. doi: 10.1002/hep.24283. Epub 2011 May 14.
10
Eradication of hepatitis C virus reduces the risk of hepatocellular carcinoma in patients with compensated cirrhosis.清除丙型肝炎病毒可降低代偿性肝硬化患者发生肝细胞癌的风险。
Dig Dis Sci. 2011 Jun;56(6):1853-61. doi: 10.1007/s10620-011-1621-2. Epub 2011 Mar 5.