Kumar Praveen A S, Talari Keerthi, Dutta T K
Department of Medicine, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Pondicherry, India.
Toxicol Int. 2012 Jan;19(1):77-8. doi: 10.4103/0971-6580.94503.
Hair dye poisoning is not rare but is an emerging poisoning in India. The main component of hair dye causing toxicity is paraphenylenediamine (PPD). Acute poisoning by PPD causes characteristic severe angioedema of the upper airway accompanied by a swollen, dry, hard, and protruding tongue. Systemic intoxication results in multisystem involvement and can cause rhabdomyolysis, acute renal failure (ARF). PPD consumption is an uncommon cause of ARF. There is no specific antidote for PPD and treatment is mainly supportive. We report a case of suicidal ingestion of hair dye that presented with cervicofascial edema and later developed rhabdomyolysis and ARF. Our patient improved with dialysis and symptomatic management.
染发剂中毒并不罕见，但在印度是一种新出现的中毒情况。导致中毒的染发剂主要成分是对苯二胺（PPD）。PPD急性中毒会引起上呼吸道特征性的严重血管性水肿，伴有舌头肿胀、干燥、变硬和突出。全身中毒会导致多系统受累，并可引起横纹肌溶解、急性肾衰竭（ARF）。PPD摄入是ARF的一种不常见病因。目前尚无针对PPD的特效解毒剂，治疗主要是支持性的。我们报告一例因自杀性摄入染发剂而出现颈面部水肿，随后发展为横纹肌溶解和ARF的病例。我们的患者通过透析和对症治疗后病情好转。
