对苯二胺：变黑的可不只是头发。
Paraphenylenediamine: Blackening more than just hair.
作者信息
Gude Dilip, Bansal Dharam Pal, Ambegaonkar Rahul, Prajapati Jayaram
机构信息
Internal Medicine/Critical care, Princess Durru-Shehvar Children's and General Hospital, Purani Haveli, India.
出版信息
J Res Med Sci. 2012 Jun;17(6):584-6.
Abstract
Paraphenylenediamine is an important constituent of hair dye toxicity of which one could herald fatal complications such as rhabdomyolysis, renal failure, angioneurotic edema, and respiratory failure. We present a case of hair dye poisoning that presented with respiratory distress due to laryngeal edema and later developed trismus, subclinical tetany, apnea, and conduction abnormality on electrocardiogram. This case report highlights the need for a thorough toxicological review of the components of any ingested substance.
摘要
对苯二胺是染发剂的一种重要成分，其毒性可能引发致命并发症，如横纹肌溶解、肾衰竭、血管神经性水肿和呼吸衰竭。我们报告一例染发剂中毒病例，患者因喉部水肿出现呼吸窘迫，随后发展为牙关紧闭、亚临床手足搐搦、呼吸暂停以及心电图传导异常。本病例报告强调了对任何摄入物质成分进行全面毒理学评估的必要性。
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本文引用的文献
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2
3
Hair dye poisoning--an emerging problem in the tropics: an experience from a tertiary care hospital in South India.染发剂中毒——热带地区一个新出现的问题：来自印度南部一家三级护理医院的经验。
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Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin-Darby canine kidney cells.对苯二胺通过氧化应激诱导 Mardin-Darby 犬肾细胞中的 DNA 损伤和细胞凋亡，并增强半胱天冬酶-8 和 -9 的活性。
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