Hassanzadeh J, Mohammadi R, Rajaeefard A R, Bordbar M R, Karimi M
Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran Red Crescent Med J. 2011 Jun;13(6):398-403. Epub 2011 Jun 1.
The causes of childhood leukemia as the most common malignancy in children are vastly unknown.The aim of this study is to evaluate the relationship between maternal birth characteristics with environmental exposures in childhood leukemia.
This is a case-control study which consists of children younger than 18 years old suffering from leukemia who reside at Fars Province of Iran. Patients were individually matched with variables such as age, sex and residence region. In order to evaluate the relationships between each variable and the risk of leukemia, odds ratio(OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.
Statistically, the association between risk of childhood leukemia with birth order (OR=6.177, 95%CI:2.551-14.957), pet ownership (OR=2.565, 95%CI: 1.352-4.868) and history of leukemia in first and second degree relatives (OR=2.667, 95%CI: 1.043-6.815) was significant. However, there was no significant association between daycare attendance, history of miscarriage, number of siblings and history of mother's diagnostic radiology tests with risk of childhood leukemia.
Although no definite etiologic factor for acute childhood leukemia has been clearly defined, the contribution of environmental risk factors in the context of genetic predisposition are strongly elucidated.
儿童白血病作为儿童最常见的恶性肿瘤，其病因大多未知。本研究旨在评估母亲生育特征与儿童白血病环境暴露之间的关系。
这是一项病例对照研究，研究对象为居住在伊朗法尔斯省的18岁以下白血病患儿。患者根据年龄、性别和居住地区等变量进行个体匹配。为了评估每个变量与白血病风险之间的关系，使用条件逻辑回归估计比值比（OR）和95%置信区间（CI）。
从统计学角度来看，儿童白血病风险与出生顺序（OR = 6.177，95%CI：2.551 - 14.957）、养宠物情况（OR = 2.565，95%CI：1.352 - 4.868）以及一级和二级亲属的白血病病史（OR = 2.667，95%CI：1.043 - 6.815）之间的关联具有显著性。然而，日托情况、流产史、兄弟姐妹数量以及母亲的诊断性放射学检查史与儿童白血病风险之间没有显著关联。
尽管尚未明确界定急性儿童白血病的确切病因，但在遗传易感性背景下环境危险因素的作用得到了有力阐明。
