Egfl7 促进肿瘤逃避免疫。
Egfl7 promotes tumor escape from immunity.
机构信息
CNRS UMR8161; Institut de Biologie de Lille; Lille, France.
出版信息
Oncoimmunology. 2012 May 1;1(3):375-376. doi: 10.4161/onci.18964.
Abstract
Egfl7 is an endothelial-specific gene which expression is deregulated in human cancers. We showed that Egfl7 promotes tumor escape from immunity by downregulating the expression of leukocyte adhesion molecules in endothelial cells, thus repressing immune cell extravasation into tumors.
摘要
Egfl7 是一种内皮细胞特异性基因，其表达在人类癌症中失调。我们表明，Egfl7 通过下调内皮细胞中白细胞黏附分子的表达，促进肿瘤逃避免疫，从而抑制免疫细胞浸润到肿瘤中。
Zotero 插件