Maeda Reiko, Ida Tomoaki, Ihara Hideshi, Sakamoto Tatsuji
Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Biosci Biotechnol Biochem. 2012;76(5):1032-4. doi: 10.1271/bbb.120016. Epub 2012 May 7.
β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.
β-1,3-木聚糖是从绿藻蕨藻中制备得到的，并通过温和的酸处理水解成低聚糖。其平均聚合度约为5。这些低聚糖以剂量依赖的方式减少了人乳腺癌MCF-7细胞的存活数量，并诱导了染色质浓缩和聚ADP-核糖聚合酶的降解，表明它们诱导了MCF-7细胞的凋亡。
