含有纳米颗粒包裹稻草半纤维素的合生元酸奶，用于即时益生菌支持和益生元递送。
Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery.
作者信息
Ismail Shaymaa A, Fayed Bahgat, El-Sayed Hoda S, Taie Hanan A A, Hassan Amira A
机构信息
Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
Dairy Department, Food Industries and Nutrition Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
出版信息
NPJ Sci Food. 2025 Aug 18;9(1):177. doi: 10.1038/s41538-025-00539-z.
This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylooligosaccharides (48.3% reducing sugars), with notable antioxidant activity (45.59 µmol Trolox/mg) and anticancer effects (61.98% reduction in EAC cell viability at 1000 µg/mL). It enhanced the growth of Lactiplantibacillus paraplantarum and Bifidobacterium bifidum more effectively than inulin. Biosafety tests in rats confirmed no adverse effects and improved lipid profiles. RSHH was successfully encapsulated into PLGA nanoparticles (38.77% efficiency, 204.9 nm size, -18.3 mV zeta potential), with spherical morphology, uniform distribution and no aggregation as confirmed by TEM. Yogurt containing both free and entrapped RSHH demonstrated the best performance over 20 days. This dual-delivery system offers a promising solution to enhance probiotic viability and prebiotic stability in functional food applications.
本研究提出了一种新型的合生元酸奶，其添加了游离的和聚乳酸-羟基乙酸共聚物（PLGA）包裹的稻草半纤维素水解产物（RSHH），以提供即时的益生菌支持和持续的益生元递送。通过酶水解获得的RSHH，每克半纤维素产生0.5克产物，富含低聚木糖（48.3%的还原糖），具有显著的抗氧化活性（45.59微摩尔 Trolox/毫克）和抗癌作用（在1000微克/毫升时，艾氏腹水癌细胞（EAC）活力降低61.98%）。与菊粉相比，它能更有效地促进植物乳杆菌和双歧双歧杆菌的生长。在大鼠身上进行的生物安全性测试证实没有不良影响，并且改善了血脂水平。RSHH成功地被包裹在PLGA纳米颗粒中（包封效率为38.77%，尺寸为204.9纳米，zeta电位为-18.3毫伏），透射电子显微镜证实其具有球形形态、均匀分布且无聚集现象。含有游离和包裹RSHH的酸奶在20天内表现出最佳性能。这种双重递送系统为在功能性食品应用中提高益生菌活力和益生元稳定性提供了一个有前景的解决方案。
Zotero 插件