来自海洋生物资源的多糖及其对乳腺癌的抗癌活性。
Polysaccharides from marine biological resources and their anticancer activity on breast cancer.
作者信息
Yang Shengfeng, Li Dacheng, Liu Weili, Chen Xiaolin
机构信息
Department of Oncology, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital China
Department of Nuclear Medicine, Affiliated Hospital of Qingdao University China
出版信息
RSC Med Chem. 2023 Apr 13;14(6):1049-1059. doi: 10.1039/d3md00035d. eCollection 2023 Jun 22.
Abstract
In recent decades, natural products from marine organisms have been widely studied for the treatment of various breast cancers. Among them, polysaccharides have been favored by researchers because of their good effects and safety. In this review, polysaccharides from marine algae including macroalgae and microalgae, chitosan, microorganisms such as marine bacteria and fungi, and starfish are addressed. Their anticancer activities on different breast cancers and action mechanisms are discussed in detail. In general, polysaccharides from marine organisms are potential sources of low side-effect and high efficiency anticancer drugs for development. However, further research on animals and clinical research are needed.
摘要
近几十年来，来自海洋生物的天然产物已被广泛研究用于治疗各种乳腺癌。其中，多糖因其良好的效果和安全性而受到研究人员的青睐。在这篇综述中，涉及了来自大型藻类和微藻等海藻的多糖、壳聚糖、海洋细菌和真菌等微生物以及海星。详细讨论了它们对不同乳腺癌的抗癌活性和作用机制。总体而言，海洋生物来源的多糖是开发低副作用、高效率抗癌药物的潜在来源。然而，还需要进一步的动物研究和临床研究。
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