Department of Internal Medicine IV, Medical Faculty, Safarik University, Kosice, Slovakia.
Med Sci Monit. 2012 Jul;18(7):PR13-7. doi: 10.12659/msm.883191.
Airway inflammation represents the basis of respiratory allergic disease and is generally associated with increased oxidative stress. As a consequence of successful treatment leading to hyposenzibilization and remission of symptoms, decrease of reactive oxygen formation is expected.
MATERIAL/METHODS: This preliminary study evaluates the production of oxygen free radicals in white blood cells and changes in basic immunological parameters in a cohort of 50 patients (27 females and 23 males, age 14-48 years) with upper airway allergic inflammation caused by pollens, before and during specific immunotherapy.
We found an unexpected significant increase in the free radical concentration during and after treatment in comparison to values before the treatment and to the control group. Statistical analysis also found significant increase of IgG3 after initial treatment and also 1 year after allergen immunotherapy. Although there were similar trends in the elevated ROS and elevated IgG3, these were not statistically significant.
We observed changes in oxidative mechanisms in white blood cells of patients treated with AIT. Allergen immunotherapy works at a multilayer level and influences airway inflammation as well as the protective antimicrobial defense in treated patients. Further studies for understanding the mechanisms involved in oxidative stress as well as for laboratory monitoring of therapeutic approaches in allergic diseases are needed.
气道炎症是呼吸道过敏性疾病的基础，通常与氧化应激增加有关。成功的治疗可以导致减敏和症状缓解，预计活性氧形成减少。
材料/方法：本初步研究评估了由花粉引起的上呼吸道过敏炎症的 50 例患者（27 名女性和 23 名男性，年龄 14-48 岁）在特异性免疫治疗前后白细胞中自由基的产生和基本免疫参数的变化。
与治疗前和对照组相比，我们发现治疗过程中和治疗后自由基浓度意外显著增加。统计分析还发现初始治疗后 IgG3 以及过敏原免疫治疗 1 年后也显著增加。尽管 ROS 和 IgG3 的升高有类似的趋势，但没有统计学意义。
我们观察到接受 AIT 治疗的患者白细胞氧化机制发生变化。变应原免疫疗法在多个层面发挥作用，影响治疗患者的气道炎症和保护性抗菌防御。需要进一步研究以了解氧化应激相关机制以及过敏性疾病的实验室监测治疗方法。
