Massa M, De Amici M, Ravelli A, Albani S, Viola S, De Benedetti F, Giaccari M C, Martini A
Clinica Pediatrica, Università di Pavia.
Minerva Pediatr. 1990 Jul-Aug;42(7-8):273-6.
Unstimulated and pokeweed mitogen (PWM)-stimulated "in vitro" IgM synthesis by peripheral blood lymphocytes has been evaluated by an ELISA method in 33 patients with juvenile rheumatoid arthritis (JRA). Lymphocyte PWM responses were significantly reduced in patients with JRA compared with healthy controls. When patients were divided according to disease activity, a significant increase of stimulation index (ratio of IgM synthesis with over that without PWM) has been observed in patients with disease remission compared with those with active disease. These findings confirm the defect in PWM-induced IgM synthesis by peripheral blood lymphocytes of patients with JRA and suggest that these abnormalities may be related to disease activity.
采用酶联免疫吸附测定（ELISA）法，对33例青少年类风湿性关节炎（JRA）患者外周血淋巴细胞的非刺激状态及经美洲商陆丝裂原（PWM）刺激后的“体外”IgM合成情况进行了评估。与健康对照相比，JRA患者淋巴细胞对PWM的反应显著降低。根据疾病活动度对患者进行分组后发现，与疾病活动期患者相比，疾病缓解期患者的刺激指数（PWM刺激后与未刺激时IgM合成量之比）显著升高。这些发现证实了JRA患者外周血淋巴细胞在PWM诱导的IgM合成方面存在缺陷，并提示这些异常可能与疾病活动度有关。
