Gershwin M E, Haselwood D, Dorshkind K, Castles J J
J Clin Lab Immunol. 1979 Feb;1(4):293-7.
Thirty patients with juvenile rheumatoid arthritis (JRA) were compared to an age-matched control population with respect to lymphocyte transformation by the mitogens Concanavalin A, Phytohemagglutinin-P, Pokeweed and Lipopolysaccharide, as well as for the relative frequency of E-rosette and Ig-bearing cells in peripheral blood. The data were analysed according to sex, age of onset, mode of onset and disease activity. Lymphocytes from patients with a pauciarticular pattern of onset of JRA responded to mitogens in a similar fashion as normal volunteers, whereas lymphocytes from patients with both a polyarticular and Still's mode of onset had a diminished response to the mitogens. However, this reduction was noteworthy only during periods of disease activity; during periods of remission, lymphocytes from the patients responded similarly to lymphocytes from normals. In contrast to this reduction in mitogen stimulation in these subgroups of patients with JRA, all patients with JRA--irrespective of disease activity or mode of onset--were similar to controls with respect to the percentage of E-rosette and Ig-bearing cells. These alterations in mitogen responsiveness could not be attributed to therapy. Finally, the abnormalities of lymphocyte transformation in patients with polyarticular and Still's mode of onset represent secondary features of disease and are not due to a generalized predisposition or abnormality of cell mediated immunity.
将30例青少年类风湿性关节炎（JRA）患者与年龄匹配的对照人群进行比较，观察其对促细胞分裂剂刀豆球蛋白A、植物血凝素-P、商陆和脂多糖的淋巴细胞转化情况，以及外周血中E花环和免疫球蛋白阳性细胞的相对频率。根据性别、发病年龄、发病方式和疾病活动度对数据进行分析。少关节型JRA患者的淋巴细胞对促细胞分裂剂的反应方式与正常志愿者相似，而多关节型和斯蒂尔病型发病的患者的淋巴细胞对促细胞分裂剂的反应减弱。然而，这种降低仅在疾病活动期值得注意；在缓解期，患者的淋巴细胞反应与正常人的淋巴细胞相似。与JRA患者这些亚组中促细胞分裂剂刺激的降低相反，所有JRA患者——无论疾病活动度或发病方式如何——在E花环和免疫球蛋白阳性细胞百分比方面与对照组相似。促细胞分裂剂反应性的这些改变不能归因于治疗。最后，多关节型和斯蒂尔病型发病的患者淋巴细胞转化异常是疾病的次要特征，并非由于细胞介导免疫的普遍易感性或异常。
