Oen K
J Rheumatol. 1985 Aug;12(4):728-34.
In vitro pokeweed mitogen (PWM) induced immunoglobulin (Ig) synthesis by lymphocytes of 33 patients with juvenile rheumatoid arthritis (JRA) was assessed and the results were correlated with clinical characteristics and laboratory measurements of disease activity. Comparisons with results of lymphocytes from adult controls and age related controls, greater than or equal to 12 years, showed reduced responses in patients with JRA. Low responders had significantly higher sedimentation rates (p = .0052) and platelet counts (p = .033), than patients with normal results. No correlations with onset subtype, medications, or age were found. These findings suggest a reduction in in vitro PWM induced B cell differentiation in patients with JRA, which may be related to disease activity.
评估了33例青少年类风湿性关节炎（JRA）患者淋巴细胞经体外商陆有丝分裂原（PWM）诱导的免疫球蛋白（Ig）合成情况，并将结果与疾病活动的临床特征和实验室检测指标进行关联分析。与成年对照组及年龄≥12岁的年龄相关对照组淋巴细胞的结果相比，JRA患者的反应降低。反应低下者的血沉率（p = 0.0052）和血小板计数（p = 0.033）显著高于结果正常的患者。未发现与发病亚型、用药情况或年龄存在相关性。这些发现提示JRA患者体外PWM诱导的B细胞分化降低，这可能与疾病活动有关。
