Department of Plant and Microbial Biology, School of Public Health, University of California, Berkeley, California, USA.
J Virol. 2012 Sep;86(17):9527-30. doi: 10.1128/JVI.01230-12. Epub 2012 Jun 27.
Infection with gammaherpesviruses, alphaherpesviruses, and betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly by a single viral factor. Although not homologous, these factors exhibit significant mechanistic similarities. In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and the position of the primary cleavage differ. Thus, multiple host shutoff factors have converged upon a common mRNA degradation pathway.
γ疱疹病毒、α疱疹病毒和β冠状病毒的感染可导致广泛的 mRNA 降解，在每种情况下主要由单个病毒因子引发。尽管这些因子不具有同源性，但它们表现出显著的机制相似性。在细胞中，每个因子都针对可翻译的 RNA 进行切割，并需要宿主 Xrn1 来完成 RNA 降解，尽管靶向机制和主要切割位置不同。因此，多种宿主关闭因子已经趋同于一个共同的 mRNA 降解途径。
