Dobashi Mamiko, Isonishi Seiji, Morikawa Asuka, Takahashi Kazuaki, Ueda Kazu, Umezawa Satoshi, Kobayashi Yoichi, Iwashita Mitsutoshi, Takechi Kimihiro, Tanaka Tadao
Department of Obstetrics/Gynecology, Jikei Daisan Hospital, Komae-shi, Tokyo 201-8601.
Oncol Lett. 2012 Mar;3(3):577-580. doi: 10.3892/ol.2011.545. Epub 2011 Dec 29.
The objective of this study was to ascertain the evidence on ovarian cancer during pregnancy and compile recommendations derived from this information. This was a retrospective study, based on clinical histories from patients diagnosed and treated at 4 independent hospitals for ovarian cancer during pregnancy, between 1992 and 2009. The median age at diagnosis was 30 years (range, 24-41). Out of 10 cases of ovarian cancer, 2 patients showed either bleeding or abdominal pain, while 8 patients were asymptomatic. All 10 cases were diagnosed via ultrasound, and the masses were detected in the first trimester in 7 patients and in the second trimester in 2 patients. Of the diagnosed tumors, 8 cases were epithelial tumors including 6 adenocarcinomas and 2 borderline tumors, and 2 germ cell tumors. The primary ovarian malignancies were at stage I of the disease. Unilateral salpingo-oophorectomy was performed in 9 patients and cystectomy was performed in one patient. Chemotherapy was administered to 4 patients, in 1 case during pregnancy. Neonatal outcome analysis showed a full- or pre-term delivery in 6 cases, abortion in 1 case and therapeutic termination in 3 cases. The majority of cases of ovarian cancer in pregnancy were incidentally detected by ultrasound at an early stage, resulting in good prognosis for the mother and the neonate.
本研究的目的是确定妊娠期间卵巢癌的相关证据，并根据这些信息制定建议。这是一项回顾性研究，基于1992年至2009年间在4家独立医院诊断和治疗的妊娠合并卵巢癌患者的临床病史。诊断时的中位年龄为30岁（范围24 - 41岁）。在10例卵巢癌病例中，2例患者出现出血或腹痛，8例患者无症状。所有10例均通过超声诊断，7例患者在孕早期发现肿块，2例在孕中期发现。在诊断出的肿瘤中，8例为上皮性肿瘤，包括6例腺癌和2例交界性肿瘤，2例为生殖细胞肿瘤。原发性卵巢恶性肿瘤处于疾病的I期。9例患者行单侧输卵管卵巢切除术，1例患者行囊肿切除术。4例患者接受了化疗，其中1例在孕期进行。新生儿结局分析显示，6例足月或早产，1例流产，3例治疗性终止妊娠。大多数妊娠合并卵巢癌病例是在早期通过超声偶然发现的，这对母亲和新生儿都有良好的预后。
