Dubnov-Raz Gal, Azar Meital, Reuveny Ronen, Constantini Naama W, Katz Uriel
Exercise, Nutrition and Lifestyle Clinic, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Harefuah. 2012 Feb;151(2):90-3, 127.
Overall, more than 80% of children diagnosed with cancer will survive their immediate disease. This growing group of childhood cancer survivors is at an increased risk for several chronic diseases and increased mortality. Physical activity is a well-known and powerful means to reduce such complications, yet many children are not active as recommended. Furthermore, the complex treatments might adversely affect the heart and lungs, possibly limiting physical performance.
To measure aerobic fitness among childhood cancer survivors, while assessing maximal cardiac and respiratory functions.
Eighteen children (mean age 11.5 +/- 2.1 years, 50% males) who had completed medical treatment for cancer, and 16 healthy children, performed a cardiorespiratory exercise test on a bicycle ergometer until exhaustion. Peak oxygen uptake, O2 pulse and several ventilatory parameters were measured and compared between the groups.
The mean maximal load obtained by the cancer survivor group was lower than expected, compared with controls (89% +/- 19 vs. 101/% +/- 18, p = 0.055). Peak oxygen consumption was also lower, with a marginal statistical significance (33.3 +/- 7.5 vs. 38.9 +/- 9.7 ml O2/kg/min, p = 0.075), yet was significantly lower when expressed as a percent of age- and sex- appropriate norms [78% +/- 15 vs. 94% +/- 16, p = 0.0081. Cardiac and respiratory functions were normal in all children, with no between-group differences.
We conclude that aerobic fitness is lower in children who have survived cancer, with no evidence of significant cardiac or lung damage. Given the importance of regular physical activity for this at-risk population, it should be continuously encouraged, while administering a personally tailored exercise prescription.
总体而言，超过80%被诊断患有癌症的儿童能够从当前疾病中存活下来。这一不断壮大的儿童癌症幸存者群体面临着多种慢性疾病风险增加和死亡率上升的问题。体育活动是减少此类并发症的一种广为人知且有效的手段，但许多儿童并未按照建议保持活跃。此外，复杂的治疗可能会对心脏和肺部产生不利影响，可能会限制身体机能。
测量儿童癌症幸存者的有氧适能，同时评估最大心脏和呼吸功能。
18名完成癌症治疗的儿童（平均年龄11.5±2.1岁，50%为男性）和16名健康儿童在自行车测力计上进行心肺运动测试，直至力竭。测量并比较两组的峰值摄氧量、氧脉搏和几个通气参数。
与对照组相比，癌症幸存者组获得的平均最大负荷低于预期（89%±19 vs. 101%±18，p = 0.055）。峰值耗氧量也较低，具有边缘统计学意义（33.3±7.5 vs. 38.9±9.7 ml O2/kg/min，p = 0.075），但以年龄和性别适宜标准的百分比表示时显著较低[78%±15 vs. 94%±16，p = 0.008]。所有儿童的心脏和呼吸功能均正常，组间无差异。
我们得出结论，癌症幸存者儿童的有氧适能较低，且没有明显心脏或肺部损伤的证据。鉴于定期体育活动对这一高危人群的重要性，在制定个性化运动处方的同时，应持续鼓励他们进行体育活动。
