Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China.
Curr Eye Res. 2013 Jan;38(1):91-6. doi: 10.3109/02713683.2012.704477. Epub 2012 Jun 28.
to evaluate and compare the interaction of silicone oil-intraocular lens (IOLs) biomaterial in 2-methacryloyloxyethyl phosphoryl-choline (MPC) -modified IOLs and various widely used IOLs in vitro.
Five groups of foldable IOLs, including 3-piece hydrophobic silicone IOLs, MPC-modified silicone IOLs, 3-piece hydrophilic hydrogel IOLs, one-piece hydrophilic acrylic IOLs and one-piece hydrophobic acrylic IOLs were photographed after immersion in silicone oil. The silicone oil coverage of the anterior and posterior surfaces of each IOL was measured using EPCO Image-analysis software. The hydrophilicity of the IOL surface was characterized by the water contact angle.
hydrophilic IOLs, such as MPC-modified silicone IOLs, hydrophilic acrylic IOLs and hydrogel IOLs having a lower contact angle exhibited less silicone oil adherence than hydrophobic IOLs, including both silicone IOLs and hydrophobic acrylic IOLs (p = 0.000, p < 0.05).
MPC-modified hydrophilic silicone IOLs reduce silicone oil adherence, and thus may meet the need of a foldable IOL suitable for vitreoretinal patients.
评估和比较硅酮油-人工晶状体（IOL）生物材料在 2-（甲基丙烯酰氧）乙基磷酰胆碱（MPC）改性 IOL 与各种广泛使用的 IOL 中的体外相互作用。
将五组折叠式 IOL 包括 3 件式疏水性硅酮 IOL、MPC 改性硅酮 IOL、3 件式亲水性水凝胶 IOL、单件亲水性丙烯酸 IOL 和单件疏水性丙烯酸 IOL 浸泡在硅油中后进行拍照。使用 EPCO 图像分析软件测量每个 IOL 前后表面的硅油覆盖面积。通过水接触角来描述 IOL 表面的亲水性。
亲水 IOL，如 MPC 改性硅酮 IOL、亲水丙烯酸 IOL 和水凝胶 IOL 的接触角较低，与疏水 IOL 相比，如硅酮 IOL 和疏水性丙烯酸 IOL，其硅油附着较少（p = 0.000，p < 0.05）。
MPC 改性亲水硅酮 IOL 减少了硅油的附着，因此可能满足适用于玻璃体视网膜患者的折叠式 IOL 的需求。
