Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, PR China.
Brain Res Bull. 2012 Sep 1;88(6):560-5. doi: 10.1016/j.brainresbull.2012.06.006. Epub 2012 Jun 26.
Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect the brain against oxidative damage and modulate the capacity of the brain to cope with synaptic dysfunction and cognitive impairment. However, no studies have investigated the effects of hydrogen-rich saline on cognitive deficits after TBI. In the present study, rats with fluid percussion injury (FPI) were used to investigate the protective effects of hydrogen-rich saline. The results showed that hydrogen-rich saline reduced the level of malondialdehyde (MDA) and elevated the level of silent information regulator 2 (Sir2). In addition, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (BDNF)-mediated synaptic plasticity, improved cognitive performance in the Morris water maze after mild TBI. These results suggest that hydrogen-rich saline can protect the brain against the deleterious effects of mild TBI on synaptic plasticity and cognition and that hydrogen-rich saline could be an effective therapeutic strategy for patients with cognitive deficits after TBI.
氧化应激是外伤性脑损伤（TBI）的主要因素，它引发的一系列事件会导致神经元长期功能障碍和重塑。重要的是，抗氧化剂可以保护大脑免受氧化损伤，并调节大脑应对突触功能障碍和认知障碍的能力。然而，目前还没有研究探讨富氢生理盐水对 TBI 后认知缺陷的影响。在本研究中，利用液压冲击伤（FPI）大鼠模型来研究富氢生理盐水的保护作用。结果表明，富氢生理盐水降低了丙二醛（MDA）的水平，提高了沉默信息调节因子 2（Sir2）的水平。此外，富氢生理盐水治疗可提高与脑源性神经营养因子（BDNF）介导的突触可塑性相关的分子水平，改善轻度 TBI 后 Morris 水迷宫中的认知表现。这些结果表明，富氢生理盐水可以保护大脑免受轻度 TBI 对突触可塑性和认知功能的有害影响，富氢生理盐水可能是 TBI 后认知障碍患者的一种有效治疗策略。
