Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
Mol Med. 2022 Mar 3;28(1):27. doi: 10.1186/s10020-022-00455-y.
Acute lung injury (ALI) and acute respiratory distress syndrome, which is a more severe form of ALI, are life-threatening clinical syndromes observed in critically ill patients. Treatment methods to alleviate the pathogenesis of ALI have improved to a great extent at present. Although the efficacy of these therapies is limited, their relevance has increased remarkably with the ongoing pandemic caused by the novel coronavirus disease 2019 (COVID-19), which causes severe respiratory distress syndrome. Several studies have demonstrated the preventive and therapeutic effects of molecular hydrogen in the various diseases. The biological effects of molecular hydrogen mainly involve anti-inflammation, antioxidation, and autophagy and cell death modulation. This review focuses on the potential therapeutic effects of molecular hydrogen on ALI and its underlying mechanisms and aims to provide a theoretical basis for the clinical treatment of ALI and COVID-19.
急性肺损伤（ALI）和急性呼吸窘迫综合征是一种更严重的 ALI 形式，是重症患者中观察到的危及生命的临床综合征。目前，缓解 ALI 发病机制的治疗方法已经有了很大的改善。尽管这些疗法的疗效有限，但随着由新型冠状病毒病 2019（COVID-19）引起的大流行，其相关性显著增加，COVID-19 导致严重的呼吸窘迫综合征。多项研究表明，分子氢在各种疾病中的预防和治疗作用。分子氢的生物学效应主要包括抗炎、抗氧化、自噬和细胞死亡调节。本综述重点介绍了分子氢对 ALI 的潜在治疗作用及其潜在机制，并旨在为 ALI 和 COVID-19 的临床治疗提供理论依据。
