Emergency Department, Naval Hospital of Eastern Theater, Zhoushan, Zhejiang Province; Neurovascular Center, Changhai Hospital, Shanghai, China.
Neurovascular Center, Changhai Hospital, Shanghai, China.
Med Gas Res. 2023 Oct-Dec;13(4):212-218. doi: 10.4103/2045-9912.344980.
The medical use of molecular hydrogen, including hydrogen-rich water and hydrogen gas, has been extensively explored since 2007. This article aimed to demonstrate the trend in medical research on molecular hydrogen. A total of 1126 publications on hydrogen therapy were retrieved from the PubMed database until July 30, 2021. From 2007 to 2020, the number of publications in this field had been on an upward trend. Medical Gas Research, Scientific Report and Shock have contributed the largest number of publications on this topic. Researchers by the name of Xue-Jun Sun, Ke-Liang Xie and Yong-Hao Yu published the most studies in the field. Analysis of the co-occurrence of key words indicated that the key words "molecular hydrogen," "hydrogen-rich water," "oxidative stress," "hydrogen gas," and "inflammation" occurred most frequently in these articles. "Gut microbiota," "pyroptosis," and "COVID-19" occurred the most recently among the keywords. In summary, the therapeutic application of molecular hydrogen had attracted much attention in these years. The advance in this field could be caught up by subscribing to relevant journals or following experienced scholars. Oxidative stress and inflammation were the most important research directions currently, and gut microbiota, pyroptosis, and coronavirus disease 2019 might become hotspots in the future.
自 2007 年以来，分子氢（包括富氢水和氢气）在医学中的应用已经得到了广泛的探索。本文旨在展示分子氢医学研究的趋势。从 2007 年到 2020 年，该领域的出版物数量呈上升趋势。在这个主题上发表最多文章的研究人员是 Xue-Jun Sun、Ke-Liang Xie 和 Yong-Hao Yu。对关键词共现的分析表明，这些文章中出现频率最高的关键词是“分子氢”、“富氢水”、“氧化应激”、“氢气”和“炎症”。而“肠道微生物群”、“细胞焦亡”和“COVID-19”则是最近出现的关键词。总之，近年来，分子氢的治疗应用引起了广泛关注。通过订阅相关期刊或关注经验丰富的学者，可以了解该领域的最新进展。氧化应激和炎症是目前最重要的研究方向，而肠道微生物群、细胞焦亡和 2019 年冠状病毒病可能成为未来的热点。
