用于细胞成像和 siRNA 递送的无毒量子点文库的生成。
Generation of a library of non-toxic quantum dots for cellular imaging and siRNA delivery.
机构信息
Department of Chemistry and Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA.
出版信息
Adv Mater. 2012 Aug 2;24(29):4014-9. doi: 10.1002/adma.201201019. Epub 2012 Jun 29.
Abstract
The development of non-toxic quantum dots and further investigation of their composition-dependent cytotoxicity in a high-throughput manner have been critical challenges for biomedical imaging and gene delivery. Herein, we report a rapid sonochemical synthetic methodology for generating a library of highly biocompatible ZnS-AgInS(2) (ZAIS) quantum dots for cellular imaging and siRNA delivery.
摘要
开发无毒量子点，并以高通量的方式进一步研究其组成依赖性细胞毒性，这一直是生物医学成像和基因传递的关键挑战。在此，我们报告了一种快速声化学合成方法，用于生成用于细胞成像和 siRNA 递送的高生物相容性 ZnS-AgInS2（ZAIS）量子点库。
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