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用于细胞成像和生物传感应用的生物纳米复合明胶/量子点

Bio-Nanohybrid Gelatin/Quantum Dots for Cellular Imaging and Biosensing Applications.

机构信息

Laboratory of Biomaterials and Regenerative Medicine for Advanced Therapies, Indian Council of Medical Research-Regional Medical Research Center, Bhubaneswar 751013, Odisha, India.

Laboratory of General Biochemistry and Physical Pharmacy, Center for Nano- and Biophotonics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

出版信息

Int J Mol Sci. 2022 Oct 6;23(19):11867. doi: 10.3390/ijms231911867.

Abstract

The bio-nanohybrid gelatin protein/cadmium sulfide (Gel/CdS) quantum dots (QDs) have been designed via a facile one-pot strategy. The amino acids group of gelatin chelate Cd and grow CdS QDs without any agglomeration. The H NMR spectra indicate that during the above process there are no alterations of the gelatin protein structure conformation and chemical functionalities. The prepared Gel/CdS QDs were characterized and their potential as a system for cellular imaging and the electrochemical sensor for hydrogen peroxide (HO) detection applications were investigated. The obtained results demonstrate that the developed Gel/CdS QDs system could offer a simple and convenient operating strategy both for the class of contrast agents for cell labeling and electrochemical sensors purposes.

摘要

通过简便的一锅法设计了生物纳米杂化明胶蛋白/硫化镉(Gel/CdS)量子点。明胶中的氨基酸基团螯合 Cd 并生长出 CdS QDs,没有任何聚集。1H NMR 谱表明,在上述过程中,明胶蛋白结构构象和化学官能团没有任何改变。对制备的 Gel/CdS QDs 进行了表征,并研究了它们作为细胞成像系统和用于检测过氧化氢(HO)的电化学传感器的潜在应用。所得结果表明,所开发的 Gel/CdS QDs 系统可以为细胞标记用造影剂和电化学传感器目的的一类提供简单方便的操作策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cfa/9570018/1f1f3e18fc62/ijms-23-11867-g001.jpg

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