Department of Internal Medicine, Section of Pulmonology, DIBIMIS University of Palermo, Palermo, Italy.
J Appl Physiol (1985). 2012 Sep 1;113(5):714-8. doi: 10.1152/japplphysiol.00529.2012. Epub 2012 Jun 28.
We previously reported that responsiveness to methacholine (Mch) in the absence of deep inspiration (DI) decreased in healthy subjects after a short course of exercise training. We assessed whether a similar beneficial effect of exercise on airway responsiveness could occur in asthmatics. Nine patients (male/female: 3/6; mean age ± SD: 24 ± 2 yr) with mild untreated asthma [forced expiratory volume in 1 s (FEV(1)): 100 ± 7.4% pred; FEV(1)/vital capacity (VC): 90 ± 6.5%] underwent a series of single-dose Mch bronchoprovocations in the absence of DI in the course of a 10-wk training rowing program (6 h/wk of submaximal and maximal exercise), at baseline (week 0), and at week 5 and 10. The single-dose Mch was established as the dose able to induce ≥ 15% reduction in inspiratory vital capacity (IVC) and was administered to each subject at every challenge occasion. Five asthmatics (male/female: 1/4; mean age ± SD: 26 ± 3 yr) with similar baseline lung function (FEV(1): 102 ± 7.0% predicted; FEV(1)/VC: 83 ± 6.0%; P = 0.57 and P = 0.06, respectively) not participating in the exercise training program served as controls. In the trained group, the Mch-induced reduction in IVC from baseline was 22 ± 10% at week 0, 13 ± 11% at week 5 (P = 0.03), and 11 ± 8% at week 10 (P = 0.028). The Mch-induced reduction in FEV(1) did not change with exercise (P = 0.69). The reduction in responsiveness induced by exercise was of the same magnitude of that previously obtained in healthy subjects (50% with respect to pretraining). Conversely, Mch-induced reduction in IVC in controls remained unchanged after 10 wk (%reduction IVC at baseline: 21 ± 20%; after 10 wk: 29 ± 14%; P = 0.28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics.
我们之前曾报道，在接受短期运动训练后，健康受试者在不进行深吸气（DI）的情况下，对乙酰甲胆碱（Mch）的反应性降低。我们评估了运动对气道反应性的类似有益影响是否可能发生在哮喘患者中。9 名（男/女：3/6；平均年龄 ± 标准差：24 ± 2 岁）轻度未经治疗的哮喘患者[第 1 秒用力呼气量（FEV1）：100 ± 7.4%预测值；FEV1/肺活量（VC）：90 ± 6.5%]在为期 10 周的划船训练计划（每周 6 小时的亚最大和最大运动）过程中，在基线（第 0 周）和第 5 周和第 10 周进行了一系列无 DI 的单次 Mch 支气管激发试验。单次 Mch 被确定为能够引起吸气肺活量（IVC）降低 ≥ 15%的剂量，并在每次挑战时给予每个受试者。5 名未参加运动训练计划的哮喘患者（男/女：1/4；平均年龄 ± 标准差：26 ± 3 岁）具有相似的基础肺功能（FEV1：102 ± 7.0%预测值；FEV1/VC：83 ± 6.0%；P = 0.57 和 P = 0.06，分别）作为对照组。在训练组中，与基线相比，Mch 引起的 IVC 降低分别为第 0 周时的 22 ± 10%、第 5 周时的 13 ± 11%（P = 0.03）和第 10 周时的 11 ± 8%（P = 0.028）。运动对 Mch 引起的 FEV1 降低没有影响（P = 0.69）。运动引起的反应性降低与健康受试者之前获得的降低幅度相同（相对于训练前降低 50%）。相反，对照组中 Mch 引起的 IVC 降低在 10 周后保持不变（IVC 降低百分比：第 0 周时为 21 ± 20%；第 10 周时为 29 ± 14%；P = 0.28）。本研究表明，短期体育锻炼能够降低轻度哮喘患者的气道反应性。
