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一项关于爱尔兰阿片类药物使用者在美沙酮替代治疗中保留情况的全国性研究。

A national study of the retention of Irish opiate users in methadone substitution treatment.

机构信息

Health Services Executive, Dr. Steeven’s Hospital, Dublin 8, Ireland.

出版信息

Am J Drug Alcohol Abuse. 2012 Nov;38(6):551-8. doi: 10.3109/00952990.2012.694516. Epub 2012 Jul 2.

DOI:10.3109/00952990.2012.694516
PMID:22747484
Abstract

BACKGROUND

Retention in treatment is a key indicator of methadone treatment success. The study aims to identify factors that are associated with retention.

OBJECTIVES

To determine retention in treatment at 12 months for Irish opiate users in methadone substitution treatment and to indicate factors that increase the likelihood of retention.

METHODS

National cohort study of randomly selected opiate users commencing methadone treatment in 1999, 2001, and 2003 (n = 1269).

RESULTS

Sixty-one percent of patients attending methadone treatment remained in continuous treatment for more than 1 year. Retention in treatment at 12 months was associated with age, gender, facility type, and methadone dose. Age and gender were no longer significant when adjusted for other variables in the model. Those who attended a specialist site were twice as likely to leave methadone treatment within 12 months compared with those who attended a primary care physician. The most important predictor of retention in treatment was methadone dose. Those who received <60 mg of methadone were three times more likely to leave treatment.

CONCLUSION

Retention in methadone treatment is high in Ireland in a variety of settings. The main factors influencing retention in methadone treatment was an adequate methadone dose and access to a range of treatment settings including from primary care physicians.

SCIENTIFIC SIGNIFICANCE

Providing an adequate dose of methadone during treatment will increase the likelihood of treatment retention. Methadone treatment by the primary care physician is a successful method of retaining opioid users in treatment.

摘要

背景

治疗保留率是美沙酮治疗成功的关键指标。本研究旨在确定与保留率相关的因素。

目的

确定爱尔兰阿片类药物使用者在美沙酮替代治疗中 12 个月的治疗保留率,并指出增加保留率的因素。

方法

对 1999 年、2001 年和 2003 年随机选择的开始美沙酮治疗的阿片类药物使用者进行全国队列研究(n=1269)。

结果

61%的患者持续接受美沙酮治疗超过 1 年。12 个月时的治疗保留率与年龄、性别、机构类型和美沙酮剂量有关。在调整模型中的其他变量后,年龄和性别不再具有统计学意义。与接受初级保健医生治疗的患者相比,在专科机构就诊的患者在 12 个月内离开美沙酮治疗的可能性是其两倍。治疗保留的最重要预测因素是美沙酮剂量。接受<60mg 美沙酮的患者离开治疗的可能性是接受治疗的三倍。

结论

在爱尔兰的各种环境中,美沙酮治疗的保留率很高。影响美沙酮治疗保留率的主要因素是美沙酮剂量充足以及获得包括初级保健医生在内的一系列治疗环境的机会。

科学意义

在治疗过程中提供足够剂量的美沙酮将增加治疗保留的可能性。初级保健医生提供美沙酮治疗是将阿片类药物使用者保留在治疗中的一种成功方法。

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