McMillan M W, Seymour C J, Brearley J C
Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK.
J Small Anim Pract. 2012 Jul;53(7):393-7. doi: 10.1111/j.1748-5827.2012.01233.x.
To evaluate the isoflurane sparing effect of intratesticular lidocaine administration in dogs undergoing castration.
Thirty dogs received a standardised anaesthetic regimen including systemic analgesia with intramuscular buprenorphine at a dose of 0·02 mg/kg and intravenous carprofen at a dose of 4 mg/kg. Dogs were randomly assigned to a lidocaine group receiving 1 mg/kg lidocaine into each testis or a control group receiving no lidocaine. Baseline physiological parameters were measured after 10 minutes at an end-tidal isoflurane concentration of 1·3%. End-tidal isoflurane concentration was altered throughout surgery to maintain these parameters within 10% of baseline and recorded at five time points. T0 was baseline, T1 was the start of surgery, T2 to T3 were clamping of the testicular pedicles and T4 was skin closure. End-tidal isoflurane concentrations were compared using analysis of variance and Bonferroni tests.
Fifteen healthy dogs were included in each study group. End-tidal isoflurane concentration was significantly lower in the lidocaine group compared to the control group at T2 (P<0·01), T3 (P<0·01) and T4 (P<0·01).
Intratesticular lidocaine reduces isoflurane requirements in dogs undergoing castration.
评估睾丸内注射利多卡因对去势犬异氟烷的节省效应。
30只犬接受标准化麻醉方案，包括肌肉注射剂量为0.02mg/kg的丁丙诺啡和静脉注射剂量为4mg/kg的卡洛芬进行全身镇痛。犬被随机分为利多卡因组（每侧睾丸注射1mg/kg利多卡因）或对照组（不注射利多卡因）。在呼气末异氟烷浓度为1.3%时10分钟后测量基线生理参数。在整个手术过程中改变呼气末异氟烷浓度，以将这些参数维持在基线的10%以内，并在五个时间点记录。T0为基线，T1为手术开始，T2至T3为钳夹睾丸蒂，T4为皮肤缝合。使用方差分析和Bonferroni检验比较呼气末异氟烷浓度。
每个研究组纳入15只健康犬。在T2（P<0.01）、T3（P<0.01）和T4（P<0.01）时，利多卡因组的呼气末异氟烷浓度显著低于对照组。
睾丸内注射利多卡因可降低去势犬的异氟烷需求量。
