United BioSource Corporation, Bethesda, Maryland 20814, USA.
Urology. 2012 Jul;80(1):97-103. doi: 10.1016/j.urology.2012.03.039.
To evaluate the impact of overactive bladder (OAB) on work productivity in a large, population-based study in the United States, with an overrepresentation of minorities.
This cross-sectional, Internet-based survey was conducted among men and women aged 18-70. The lower urinary tract symptoms (LUTS) tool was used to assess symptoms over past 4 weeks. OAB was defined by urinary urgency of at least "sometimes" and/or urgency urinary incontinence (UUI). Outcomes included work status, Work Productivity and Activity Impairment Questionnaire--General Health (WPAI-GH) and Specific Health (WPAI-SH), and questions about the impact of urinary symptoms on work. Descriptive statistics were used to evaluate group differences (no/minimal symptoms [NMS] vs OAB). Logistic regressions evaluated predictors of unemployment status controlling for comorbid conditions, risk factors, and demographic variables.
The response rate was 57%. A total of 5795 men and women were included in the analysis (OAB, 2323; NMS, 3472). OAB cases were significantly more likely to be unemployed (men, 44%; women, 54%) compared to those with NMS (men, 24%; women, 41%). Mean work productivity and activity impairment (WPAI) percent impairment while working was as follows: 19% and 21% among men and women with OAB; NMS, 4% and 7%. Significant differences were found for all urinary-specific WPAI-SHP items and other condition-specific outcomes. Men with OAB were 1.5 times more likely to be unemployed as compared to those with NMS when covariates were controlled for, whereas the association between OAB and unemployment in multivariate analysis was nonsignificant among women.
Comparison with other outcomes suggests that OAB impairs work at levels comparable to other serious chronic conditions, including rheumatoid arthritis and asthma.
通过一项在美国进行的大型人群基础研究，评估膀胱过度活动症（OAB）对工作效率的影响，该研究中少数民族占比较大。
这是一项横断面、基于互联网的调查，对象为年龄在 18-70 岁的男性和女性。使用下尿路症状（LUTS）工具评估过去 4 周的症状。OAB 定义为至少“有时”出现尿急和/或急迫性尿失禁（UUI）。结果包括工作状态、工作生产力和活动障碍问卷-一般健康（WPAI-GH）和特定健康（WPAI-SH），以及尿症状对工作影响的相关问题。采用描述性统计方法评估无/轻度症状（NMS）与 OAB 组之间的差异。采用逻辑回归评估控制合并症、危险因素和人口统计学变量后失业状态的预测因素。
应答率为 57%。共纳入 5795 名男性和女性进行分析（OAB，2323 例；NMS，3472 例）。与 NMS 相比，OAB 患者更有可能失业（男性，44%；女性，54%）。男性和女性 OAB 患者的工作生产力和活动障碍（WPAI）工作时的损害百分比分别为 19%和 21%；NMS 分别为 4%和 7%。所有与尿相关的 WPAI-SHP 项目和其他特定疾病的结果均存在显著差异。在控制了协变量后，与 NMS 相比，男性 OAB 患者失业的可能性是前者的 1.5 倍，而在多变量分析中，OAB 与女性失业之间的关联无统计学意义。
与其他结果相比，OAB 对工作的损害程度与其他严重慢性疾病相当，包括类风湿关节炎和哮喘。
