Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, 100029, China.
China Academy of Chinese Medical Sciences Institute of Basic Theory in Chinese Medicine, Beijing, 100700, China.
PLoS One. 2024 May 23;19(5):e0301553. doi: 10.1371/journal.pone.0301553. eCollection 2024.
Urinary incontinence (UI) might be linked to suicidal ideation, but we do not yet have all the relevant details. This study aimed to dig deeper into the connection between UI and suicidal ideation using data from the National Health and Nutrition Examination Survey (NHANES).
We examined 31,891 participants aged ≥ 20 years from NHANES 2005-2018 who provided complete information. We used standardized surveys to check for UI and signs of suicidal ideation. To better understand this relationship, we used statistical tools such as multivariable logistic regression, subgroup analysis, and sensitivity analyses.
Among the 31,891 participants, 28.9% reported UI and 10.7% reported suicidal ideation. Those with UI exhibited a significantly greater incidence of suicidal ideation (15.5%) than did those without UI (8.8%, P < 0.001). After adjusting for various factors, including age, sex, marital status, socioeconomic status, educational level, lifestyle factors, and chronic comorbidities, UI remained significantly associated with suicidal ideation (OR:1.54, 95% CI = 1.39-1.7, P < 0.001). Among all types of UI, MUI participants were more likely to experience suicidal ideation. Compared with no UI, higher odds of suicidal ideation suffered from MUI (OR:2.11, 95%CI:1.83-2.44, P < 0.001), SUI (OR:1.4, 95%CI:1.19-1.65, P < 0.001), UUI(OR:1.37,95%CI:1.16-1.62, P < 0.001) after full adjustment. With the exception of individuals living with a partner, the remaining subgroups exhibited a positive correlation between urinary incontinence and suicidal ideation, considering that factors such as age, sex, and prevalent comorbidities such as hypertension, depression, and diabetes did not reveal any statistically significant interactions (all P > 0.05). Sensitivity analyses, incorporating imputed missing covariates, did not substantially alter the results (OR: 1.53, 95% CI: 1.4-1.68, P < 0.001).
Urinary incontinence may correlate with increased suicidal ideation risk, priority screening for suicidal ideation and timely intervention are essential for individuals with urinary incontinence, but prospective studies are needed to verify the results.
尿失禁(UI)可能与自杀意念有关,但我们尚未掌握所有相关细节。本研究旨在利用国家健康和营养检查调查(NHANES)的数据,更深入地研究 UI 与自杀意念之间的关系。
我们对 2005-2018 年 NHANES 中年龄≥20 岁且提供完整信息的 31891 名参与者进行了检查。我们使用标准化调查来检查 UI 和自杀意念的迹象。为了更好地理解这种关系,我们使用了多变量逻辑回归、亚组分析和敏感性分析等统计工具。
在 31891 名参与者中,28.9%报告有 UI,10.7%报告有自杀意念。有 UI 的参与者自杀意念的发生率明显更高(15.5%),而无 UI 的参与者为 8.8%(P<0.001)。在调整了年龄、性别、婚姻状况、社会经济状况、教育程度、生活方式因素和慢性合并症等多种因素后,UI 与自杀意念仍显著相关(OR:1.54,95%CI=1.39-1.7,P<0.001)。在所有类型的 UI 中,MUI 参与者更有可能经历自杀意念。与无 UI 相比,MUI(OR:2.11,95%CI:1.83-2.44,P<0.001)、SUI(OR:1.4,95%CI:1.19-1.65,P<0.001)和 UUI(OR:1.37,95%CI:1.16-1.62,P<0.001)患者发生自杀意念的可能性更高。在充分调整后,除了与伴侣同住的个体外,其余亚组的尿失禁与自杀意念之间存在正相关关系,因为年龄、性别以及高血压、抑郁和糖尿病等常见合并症等因素并未显示出任何具有统计学意义的交互作用(均 P>0.05)。敏感性分析纳入了缺失协变量的估算值,结果并未发生实质性改变(OR:1.53,95%CI:1.4-1.68,P<0.001)。
尿失禁可能与自杀意念风险增加相关,对尿失禁患者进行自杀意念的优先筛查和及时干预至关重要,但需要前瞻性研究来验证结果。