Muller G, Bernuzzi V, Desor D, Hutin M F, Burnel D, Lehr P R
Centre des Sciences de l'Environnement, Neurotoxicologie, Université de Metz, France.
Teratology. 1990 Sep;42(3):253-61. doi: 10.1002/tera.1420420309.
Pregnant rats were treated orally with aluminum lactate (400 mg Al/kg/day) during three periods of gestation to determine the treatment's influence on mortality, weight gain, neuromotor maturation, and learning abilities of their pups. No effect of treatment on litter size, mortality rate, and weight gain of pups was detected. In the negative geotaxis test, the scores of pups from females treated during the second and third weeks of gestation were diminished. In the locomotor coordination and the operant conditioning tests, significant differences in the comparison of controls vs. the three treated groups were found, indicating long-term effects of early intoxication upon the central nervous system.
在孕期的三个阶段，给怀孕大鼠口服乳酸铝（400毫克铝/千克/天），以确定该处理对其幼崽的死亡率、体重增加、神经运动成熟度和学习能力的影响。未检测到处理对幼崽窝仔数、死亡率和体重增加有影响。在负趋地性试验中，孕期第二和第三周接受处理的雌性大鼠所产幼崽的得分降低。在运动协调性和操作性条件反射试验中，对照组与三个处理组的比较存在显著差异，表明早期中毒对中枢神经系统有长期影响。
