乳酸铝经口染毒的妊娠和未妊娠雌性大鼠体内元素变化

Element variations in pregnant and nonpregnant female rats orally intoxicated by aluminum lactate.

作者信息

Muller G, Burnel D, Gery A, Lehr P R

机构信息

Centre des Sciences de l'Environnement, Toxicologie-Neurotoxicologie, Université de Metz, France.

出版信息

Biol Trace Elem Res. 1993 Nov-Dec;39(2-3):211-9. doi: 10.1007/BF02783191.

DOI:10.1007/BF02783191

PMID:7509178

Abstract

Pregnant or nonpregnant female rats were orally intoxicated by aluminum lactate (400 mg Al/kg/d) from d 0-19 of gestation to determine the treatment's influence on element variations in the females and their fetuses. The aluminum levels of plasma, liver, spleen, and kidneys were significantly higher in treated pregnant rats than non-pregnant female rats. Differences of P, Ca, Cu, Zn, or Mg levels were observed among the four groups of female rats in the tissues and plasma. The aluminum content of the 20-d-old fetuses did not significantly differ between the treated and control groups. On the contrary, calcium and magnesium levels in the whole fetuses from treated or nontreated dams are significantly different.

摘要

怀孕或未怀孕的雌性大鼠从妊娠第0天至第19天经口摄入乳酸铝（400毫克铝/千克/天），以确定该处理对雌性大鼠及其胎儿元素变化的影响。经处理的怀孕大鼠血浆、肝脏、脾脏和肾脏中的铝水平显著高于未怀孕的雌性大鼠。在四组雌性大鼠的组织和血浆中观察到磷、钙、铜、锌或镁水平存在差异。处理组和对照组20日龄胎儿的铝含量没有显著差异。相反，经处理或未经处理的母鼠所产整个胎儿中的钙和镁水平存在显著差异。