Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden.
Alzheimers Dement. 2012 Jul;8(4):272-7. doi: 10.1016/j.jalz.2011.05.2411.
We have shown that high mid-life central adiposity may increase the risk for dementia after 32 years. Leptin, an adipose tissue hormone, is correlated with adiposity measures and may contribute to a better etiological understanding of the relationship between high adiposity and dementia. We explored the relationship between serum leptin in mid-life and dementia, which is a late-life outcome.
A longitudinal cohort study, the Prospective Population Study of Women, in Gothenburg, Sweden, includes a representative sample of 1462 women followed from mid-life ages of 38 to 60 years to late-life ages of 70 to 92 years. Women were examined in 1968, 1974, 1980, 1992, and 2000 using neuropsychiatric, anthropometric, clinical, and other measurements. Serum leptin was measured on samples collected at the 1968 baseline examination, after storage at -20°C for 29 years. Cox proportional hazards regression models estimated incident dementia risk by baseline leptin. Logistic regression models related leptin levels to dementia among surviving participants 32 years later. All models were adjusted for multiple potential confounders.
Mid-life leptin was not related to dementia risk using Cox or logistic regression models. This was observed despite positive baseline correlations between leptin and adiposity measures, and given our previous report of high mid-life waist-to-hip ratio being related to a twofold higher dementia risk.
Leptin is not a mid-life marker of late-life dementia risk in this population sample of Swedish women born between 1908 and 1930.
我们已经表明，中年时期的中心性肥胖程度较高可能会增加 32 年后患痴呆症的风险。瘦素是一种脂肪组织激素，与肥胖指标相关，可能有助于更好地理解肥胖与痴呆症之间的关系。我们探讨了中年时期血清瘦素与痴呆症之间的关系，后者是一种老年期结局。
一项纵向队列研究——瑞典哥德堡的前瞻性妇女人群研究，包括了从中年（38-60 岁）到老年（70-92 岁）的 1462 名女性的代表性样本。在 1968 年、1974 年、1980 年、1992 年和 2000 年，通过神经精神病学、人体测量学、临床和其他测量对女性进行了检查。在 -20°C 下储存 29 年后，对 1968 年基线检查时收集的样本进行了血清瘦素测量。使用 Cox 比例风险回归模型估计了基线瘦素与痴呆症的发病风险。使用逻辑回归模型，将 32 年后仍存活的参与者的瘦素水平与痴呆症相关联。所有模型都经过了多种潜在混杂因素的调整。
使用 Cox 或逻辑回归模型，中年瘦素与痴呆症风险无关。这与基线瘦素与肥胖指标之间存在正相关一致，并且考虑到我们之前的报告表明，高中心性肥胖与痴呆症风险增加两倍有关。
在瑞典出生于 1908 年至 1930 年的女性人群样本中，中年时期的瘦素并不是老年期痴呆症风险的标志物。
