Gustafson D R, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K
Department of Psychiatry and Neurochemistry (Neuropsychiatric Epidemiology Unit), Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
J Intern Med. 2007 Dec;262(6):643-50. doi: 10.1111/j.1365-2796.2007.01869.x. Epub 2007 Nov 7.
We explored the relationship between adiposity factors measured during mid-life and blood-brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study.
Population-based sample. Subjects. Eighty-one women.
CSF/S albumin ratio.
The CSF/S albumin ratio measured at age 70-84 years was higher amongst women who were overweight or obese (6.50 +/- 2.79 vs. 5.23 +/- 1.61, age-adjusted P = 0.012), and was inversely correlated with SHBG (age-adjusted r = -0.321, P < 0.005) at age 46-60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = -0.017, R2 = 0.107, P = 0.007). The best model (R2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction.
Lower levels of SHBG in mid-life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone-mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.
我们探讨了中年时期测量的肥胖因素与老年时期通过脑脊液/血清（CSF/S）白蛋白比率测量的血脑屏障（BBB）完整性之间的关系。肥胖因素包括体重指数以及性激素结合球蛋白（SHBG）和瘦素的血液水平。设计：在一项纵向研究中进行了超过24年的回顾性分析。
基于人群的样本。受试者：81名女性。
CSF/S白蛋白比率。
在70 - 84岁时测量发现，超重或肥胖女性的CSF/S白蛋白比率更高（6.50±2.79对5.23±1.61，年龄调整后P = 0.012）；在46 - 60岁时，该比率与SHBG呈负相关（年龄调整后r = -0.321，P < 0.005）；在逐步回归模型中，SHBG可预测CSF/S白蛋白比率（β = -0.017，R2 = 0.107，P = 0.007）；预测CSF/S白蛋白比率的最佳模型（R2 = 0.187）包括SHBG、年龄组（46岁与>46岁）、超重或肥胖以及年龄组与SHBG的交互作用项。
即使考虑其他肥胖因素，中年时期较低水平的SHBG与老年女性24年后较差的BBB完整性相关。SHBG对于理解性激素介导脑健康机制或作为最大内分泌器官脂肪组织的独立标志物可能很重要
