Omega Optics Inc., 10306 Sausalito Drive, Austin, TX 78759, USA.
Biosens Bioelectron. 2012 Oct-Dec;38(1):170-6. doi: 10.1016/j.bios.2012.05.016. Epub 2012 Jun 7.
Current trends in photonic crystal microcavity biosensors in silicon-on-insulator (SOI), that focus on small and smaller sensors have faced a bottleneck trying to balance two contradictory requirements of resonance quality factor and sensitivity. By simultaneous control of the radiation loss and optical mode volumes, we show that both requirements can be satisfied simultaneously. Microcavity sensors are designed in which resonances show highest Q ≈ 9300 in the bio-ambient phosphate buffered saline (PBS) as well as highest sensitivity among photonic crystal biosensors. We experimentally demonstrated mass sensitivity 8.8 atto-grams with sensitivity per unit area of 0.8 pg/mm(2). Highest sensitivity, irrespective of the dissociation constant K(d), is demonstrated among all existing label-free optical biosensors in silicon at the concentration of 0.1 μg/ml.
在硅片上的光子晶体微腔生物传感器的当前趋势（SOI）中，重点是更小的传感器，已经面临一个瓶颈，试图平衡共振质量因子和灵敏度这两个相互矛盾的要求。通过同时控制辐射损耗和光学模式体积，我们表明这两个要求可以同时得到满足。设计的微腔传感器中，共振显示出在生物环境磷酸盐缓冲盐水（PBS）中最高的 Q ≈ 9300，以及在光子晶体生物传感器中最高的灵敏度。我们实验证明了在质量灵敏度为 8.8 飞克时，单位面积的灵敏度为 0.8 皮克/平方毫米。在 0.1 μg/ml 的浓度下，在所有现有的硅基无标记光学生物传感器中，均显示出最高的灵敏度，而与离解常数 K(d)无关。
