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用于高灵敏度光子晶体微腔生物传感器复用的硅基片上带通滤波器。

Silicon on-chip bandpass filters for the multiplexing of high sensitivity photonic crystal microcavity biosensors.

作者信息

Yan Hai, Zou Yi, Chakravarty Swapnajit, Yang Chun-Ju, Wang Zheng, Tang Naimei, Fan Donglei, Chen Ray T

机构信息

Department of Electrical and Computer Engineering, Microelectronics Research Center, The University of Texas at Austin , 10100 Burnet Rd., Austin, Texas 78758, USA.

Omega Optics, Inc. , 8500 Shoal Creek Blvd., Austin, Texas 78757, USA.

出版信息

Appl Phys Lett. 2015 Mar 23;106(12):121103. doi: 10.1063/1.4916340.

DOI:10.1063/1.4916340
PMID:25829549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4376754/
Abstract

A method for the dense integration of high sensitivity photonic crystal (PC) waveguide based biosensors is proposed and experimentally demonstrated on a silicon platform. By connecting an additional PC waveguide filter to a PC microcavity sensor in series, a transmission passband is created, containing the resonances of the PC microcavity for sensing purpose. With proper engineering of the passband, multiple high sensitivity PC microcavity sensors can be integrated into microarrays and be interrogated simultaneously between a single input and a single output port. The concept was demonstrated with a 2-channel L55 PC biosensor array containing PC waveguide filters. The experiment showed that the sensors on both channels can be monitored simultaneously from a single output spectrum. Less than 3 dB extra loss for the additional PC waveguide filter is observed.

摘要

提出了一种基于高灵敏度光子晶体(PC)波导生物传感器的密集集成方法,并在硅平台上进行了实验验证。通过将一个额外的PC波导滤波器与一个PC微腔传感器串联连接,创建了一个传输通带,其中包含用于传感目的的PC微腔的共振。通过对通带进行适当设计,多个高灵敏度PC微腔传感器可以集成到微阵列中,并在单个输入端口和单个输出端口之间同时进行检测。该概念通过一个包含PC波导滤波器的2通道L55 PC生物传感器阵列得到了验证。实验表明,两个通道上的传感器可以从单个输出光谱中同时进行监测。观察到额外的PC波导滤波器的额外损耗小于3dB。

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本文引用的文献

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The role of group index engineering in series-connected photonic crystal microcavities for high density sensor microarrays.用于高密度传感器微阵列的串联光子晶体微腔中群指数工程的作用。
Appl Phys Lett. 2014 Apr 7;104(14):141103. doi: 10.1063/1.4871012. Epub 2014 Apr 8.
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Scalable photonic crystal chips for high sensitivity protein detection.用于高灵敏度蛋白质检测的可扩展光子晶体芯片。
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Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors.基于硅基光子晶体微腔生物传感器的多重特异性无标记检测 NCI-H358 肺癌细胞系裂解物。
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