Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, 33520 Tampere, Finland.
Leuk Res. 2012 Sep;36(9):1082-8. doi: 10.1016/j.leukres.2012.06.001. Epub 2012 Jun 27.
The zebrafish has proven to be a valuable vertebrate model in which to elucidate the molecular mechanisms of various diseases. A high degree of genetic and morphological similarity in hematopoiesis between the zebrafish and human indicates that zebrafish can provide valuable knowledge about the mechanisms behind pathogenesis of leukemia. To date, a small number of zebrafish leukemia models have been published and they have already provided some interesting information. However, the full potential of these models, especially the identification of contributing genetic factors and high-throughput drug screens, is yet to be fulfilled. Further transgenic or mutant animals are needed, especially for modeling high-risk leukemias, such as MLL rearranged infant leukemias.
斑马鱼已被证明是一种有价值的脊椎动物模型，可用于阐明各种疾病的分子机制。斑马鱼和人类在造血方面具有高度的遗传和形态相似性，这表明斑马鱼可以为白血病发病机制背后的机制提供有价值的知识。迄今为止，已经发表了少数几种斑马鱼白血病模型，它们已经提供了一些有趣的信息。然而，这些模型的全部潜力，特别是鉴定致病遗传因素和高通量药物筛选，尚未得到充分发挥。还需要进一步的转基因或突变动物，特别是用于模拟高风险白血病，如 MLL 重排婴儿白血病。
