Pamukkale University, Faculty of Medicine, Department of Endocrinology and Metabolism, Denizli, 20070, Turkey.
Eat Weight Disord. 2012 Mar;17(1):e57-61. doi: 10.1007/BF03325329.
The aim of this study was to investigate the relationship between insulin resistance and thyroid function in obese pre- and postmenopausal women with or without metabolic syndrome (MetS). 141 obese women were divided into two groups, HOMA-IR<2.7 and HOMA-IR>2.7, to evaluate relation with HOMA-IR and fatness, hormone and blood parameters. They were then divided into four groups as pre- and postmenopausal with or without MetS. Various fatness, hormone and blood parameters were examined. Statistically significant difference was found in weight, body mass index (BMI), waist circumference, fat%, fasting insulin, TSH, FT3, FT4, FSH, Anti-microsomal antibody (ANTIM) and triglycerides levels in HOMA-IR<2.7 and HOMA-IR>2.7 obese Turkish women. This study showed that age, weight, BMI, waist circumference, fat%, fasting insulin, FT3, ANTIM, FSH, LH, total cholesterol, triglycerides, HDL, HOMA-IR, systolic and diastolic blood pressure levels were related in preand post menopausal status in obese women with or without MetS. Obesity may influence the levels of thyroid hormones and increases the risk of MetS in women. Postmenopausal status with MetS is associated with an increased TSH, FT3 and FT4 levels and HOMA-IR in obese women. Strong relation was observed with MetS and TSH and FT3 levels.
本研究旨在探讨肥胖绝经前和绝经后妇女中胰岛素抵抗与甲状腺功能之间的关系，无论其是否患有代谢综合征 (MetS)。将 141 名肥胖女性分为 HOMA-IR<2.7 和 HOMA-IR>2.7 两组，以评估 HOMA-IR 与肥胖、激素和血液参数之间的关系。然后，根据是否患有 MetS，将她们分为绝经前和绝经后两组。检查了各种肥胖、激素和血液参数。在 HOMA-IR<2.7 和 HOMA-IR>2.7 的肥胖土耳其女性中，体重、体重指数 (BMI)、腰围、体脂%、空腹胰岛素、TSH、FT3、FT4、FSH、抗微粒体抗体 (ANTIM) 和甘油三酯水平存在显著差异。这项研究表明，年龄、体重、BMI、腰围、体脂%、空腹胰岛素、FT3、ANTIM、FSH、LH、总胆固醇、甘油三酯、HDL、HOMA-IR、收缩压和舒张压水平在肥胖女性无论是否患有 MetS，绝经前和绝经后状态都存在相关性。肥胖可能会影响甲状腺激素水平，并增加女性患 MetS 的风险。患有 MetS 的绝经后状态与肥胖女性的 TSH、FT3 和 FT4 水平以及 HOMA-IR 升高有关。还观察到 MetS 与 TSH 和 FT3 水平之间存在很强的关系。
