大鼠心血管系统中β-肾上腺素能受体的细分
The subdivision of beta-adrenoceptors in the cardiovascular system of the rat.
作者信息
Imms F J, Neame R L, Powis D A
出版信息
Br J Pharmacol. 1979 Nov;67(3):367-70. doi: 10.1111/j.1476-5381.1979.tb08689.x.
Abstract
1 The antagonism by the beta-adrenoceptor blocking drugs, propranolol (non-selective) and practolol (beta-selective), of the cardiovascular actions of isoprenaline has been investigated in the rat. 2 All doses of practolol (0.1, 1 and 3 mg/kg) blocked the cardio-accelerator action of isoprenaline but only the largest dose blocked the vasodilator effect. 3 All doses of propranolol (0.01, 0.03 and 0.1 mg/kg) blocked the vasodilator effect of isoprenaline but only the largest dose diminished the tachycardia. 4 It is concluded that in the rat, as in other species, beta-adrenoceptors may be subdivided into beta 1 (cardiac) and beta 2 (peripheral vascular) types.
摘要
- 已在大鼠中研究了β肾上腺素受体阻断药普萘洛尔（非选择性）和美托洛尔（β选择性）对异丙肾上腺素心血管作用的拮抗作用。2. 所有剂量的美托洛尔（0.1、1和3毫克/千克）均阻断了异丙肾上腺素的心脏加速作用，但只有最大剂量阻断了血管舒张作用。3. 所有剂量的普萘洛尔（0.01、0.03和0.1毫克/千克）均阻断了异丙肾上腺素的血管舒张作用，但只有最大剂量减轻了心动过速。4. 得出结论，在大鼠中，与其他物种一样，β肾上腺素受体可分为β1（心脏）和β2（外周血管）类型。
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