Couturier D, Chaussade S
Service d'Hépato-Gastro-Entérologie, Hôpital Cochin, Paris.
Presse Med. 1988 Jan 23;17(2):69-73.
Measurement of the transit time by addition of a marker to the natural alimentary bolus permits an overall evaluation of colonic motricity. Bismuth and barium salts, dyes and radioactive compounds have been used, each of these methods having its own drawbacks, such as insufficient or impossible quantification, influence on transit or partial intestinal absorption. Radio-opaque pellets do not modify transit, are not absorbed, provide quantification readily and measure transit selectively in the ascending colon, the descending colon, the sigmoid colon and the rectum. The progression of pellets is followed by radiography of the abdomen. The number of radiograms can be reduced to 3 or even 1 by graded administration of the pellets over 3 consecutive days. The results obtained in normal subjects are similar in different studies; they are not influenced by age or by the amount of fibrous material present in food. Total and right segmental transit times are longer in women than in men. Measurement of the colonic transit time is indicated in severe constipation to differentiate between colonic inertia and terminal obstruction which have different mechanisms and treatments. Such measurements are also useful for an objective evaluation of constipation.
通过向天然食团中添加标志物来测量通过时间，可以对结肠动力进行全面评估。铋盐、钡盐、染料和放射性化合物都曾被使用过，每种方法都有其自身的缺点，比如量化不足或无法量化、对通过时间的影响或部分肠道吸收。不透射线的小丸不会改变通过时间，不会被吸收，能轻松实现量化，并且能分别测量升结肠、降结肠、乙状结肠和直肠的通过时间。通过腹部X光检查来追踪小丸的推进情况。通过连续3天分级给予小丸，X光检查的次数可减少至3次甚至1次。不同研究中在正常受试者身上获得的结果相似；它们不受年龄或食物中纤维物质含量的影响。女性的总结肠通过时间和右侧节段性通过时间比男性更长。结肠通过时间的测量适用于严重便秘，以区分结肠惰性和终末性梗阻，二者机制和治疗方法不同。此类测量对于便秘的客观评估也很有用。
