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研究小鼠习惯性行为的方法。

Methods for studying habitual behavior in mice.

作者信息

Rossi Mark A, Yin Henry H

机构信息

Department of Psychology and Neuroscience, Center for Cognitive Neuroscience, Duke University, Durham, North Carolina, USA.

出版信息

Curr Protoc Neurosci. 2012 Jul;Chapter 8:Unit 8.29. doi: 10.1002/0471142301.ns0829s60.

DOI:10.1002/0471142301.ns0829s60
PMID:22752897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3408711/
Abstract

Habit formation refers to the process by which goal-directed behavior becomes automatized and less sensitive to changes in the value of the goal. It has clear relevance for our understanding of skill learning and addiction. Recent studies have begun to reveal the neural substrates underlying this process. This unit summarizes what is known about the experimental methods used, and provides a protocol for generating and assessing habit formation in mice.

摘要

习惯形成是指目标导向行为变得自动化且对目标价值变化的敏感度降低的过程。它与我们对技能学习和成瘾的理解密切相关。最近的研究已开始揭示这一过程背后的神经基础。本单元总结了关于所使用实验方法的已知信息,并提供了一种在小鼠中产生和评估习惯形成的方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/7e2843c2aeb6/nihms-391597-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/be187da56693/nihms-391597-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/b0fdb5de63aa/nihms-391597-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/7e2843c2aeb6/nihms-391597-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/be187da56693/nihms-391597-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/b0fdb5de63aa/nihms-391597-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/3408711/7e2843c2aeb6/nihms-391597-f0003.jpg

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本文引用的文献

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Front Integr Neurosci. 2010 May 21;4. doi: 10.3389/fnint.2010.00014. eCollection 2010.
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Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement.仪器不确定度作为强化间隔时间表下行为的决定因素。
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Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation.
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A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit.一个分子定义的眶额皮质神经元群体控制着强迫样行为,但不能控制不灵活的选择或习惯。
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Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.训练诱导的小鼠特定回路兴奋性突触发生对于努力控制是必需的。
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UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation.UBE3A 蛋白在早期产后大脑发育期间的表达对于背内侧纹状体的正常成熟是必需的。
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