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[全胃切除并利用空肠构建新胃。对120例患者的回顾性研究]

[Total gastrectomy with creation of a new stomach using the jejunum. A retrospective study of 120 patients].

作者信息

Fernandes F V, Mascarenhas L, da Costa E B, Branco A, Mendonça J L

机构信息

Clínica Universitária de Cirurgia I, Unidade de Citostáticos (Medicina II), Faculdade de Medicina de Lisboa.

出版信息

Acta Med Port. 1990 Jul-Aug;3(4):213-20.

PMID:2275412
Abstract

Results obtained in 120 patients with gastric carcinoma, and submitted between 1982 and 1989, to a total gastrectomy and a new technique of reconstruction with jejunum, are analyzed retrospectively. This technique associates, a jejunoplication around the terminal esophagus with the purpose to eliminate the entero-esophageal reflux and the risk of dehiscence, and a double jejuno-jejunostomy with the target to delay the emptying of foods and to increase the reservoir function of the neo-stomach. In 63 of these patients a lymphadenectomy type R2-R3 has been held and in the remainder a type R1 lymph node dissection. Pre-operative chemotherapy was done when there was significant weight loss or proved obstruction of the cardia or pylorus by a radioisotopic method. Post-operative chemotherapy was continued immediately after operation in all the patients with pre-operative improvement. Operative mortality until the 60th day of Hospital stay was 5.8% and was mainly related with the advanced age of the patients and the spread and localization of the tumor. Operative morbidity was also more marked in tumors spreading to the cardia. The five years actuarial survival rate was 17.2% to the stage III and IV and 38.8% to the stage I and II. The quality of life of the patients has been favored by the kind of gastric reconstruction that has been used: Jejunoplication reduce the entero-esophageal reflux to nearly 20% and the double enterostomy, specially if the duodenal transit is maintained, induce a more slow post-operative emptying than other kinds of reconstruction. This fact is related with a more physiologic absorption of glucose and to a more favorable nutritional condition.

摘要

对1982年至1989年间接受全胃切除术及空肠重建新技术的120例胃癌患者的结果进行回顾性分析。该技术包括在食管末端周围进行空肠折叠术以消除肠食管反流和吻合口裂开风险,以及进行双空肠吻合术以延缓食物排空并增强新胃的储存功能。其中63例患者进行了R2 - R3型淋巴结清扫,其余患者进行了R1型淋巴结清扫。当患者体重显著减轻或经放射性同位素方法证实贲门或幽门梗阻时,进行术前化疗。所有术前病情改善的患者术后立即继续进行化疗。住院至第60天的手术死亡率为5.8%,主要与患者高龄以及肿瘤的扩散和部位有关。肿瘤扩散至贲门的患者手术发病率也更高。III期和IV期患者的五年精算生存率为17.2%,I期和II期患者为38.8%。所采用的胃重建方式有利于患者的生活质量:空肠折叠术将肠食管反流降低至近20%,双肠造口术,特别是在维持十二指肠通过的情况下,术后排空比其他类型的重建更慢。这一事实与葡萄糖更生理性的吸收以及更有利的营养状况有关。

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