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[胃癌次全切除与全胃切除术后生活质量的比较]

[Comparison of the quality of life after subtotal and total gastrectomy for stomach carcinoma].

作者信息

Roder J D, Stein H J, Eckel F, Herschbach P, Henrich G, Böttcher K, Busch R, Siewert J R

机构信息

Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München.

出版信息

Dtsch Med Wochenschr. 1996 Apr 26;121(17):543-9. doi: 10.1055/s-2008-1043038.

Abstract

OBJECTIVE

To compare quality of life after subtotal gastrectomy (STG) and total gastrectomy of various types, in view of the fact that, with T1 and T2 gastric carcinoma of intestinal type in the distal third of the stomach, subtotal gastrectomy is similar to total gastrectomy regarding the extent of lymphadenectomy and prognosis.

PATIENTS AND METHODS

Quality of life was measured by standardised questionnaires given to 36 patients after subtotal gastrectomy (22 men, 14 women; mean age 63 [27-79] years): general physical complaints (GPC); contentment with life (CL); psychosocial stress (PSS). The results were compared with those previously obtained in 58 patients with total gastrectomy (46 men, 12 women; mean age 63.4 [36-74] years) and oesophagojejunostomy (OJS) (n = 29) or oesophagojejunoplication and pouch (OJPP) (n = 29).

RESULTS

Weight loss of patients after OJPP was not significantly different from that of patients after STG, but it was significantly higher after OJS (13.5 +/- 8.6 kg; P < 0.0006). Patients with STG had significantly more general complaints (P < 0.05) and greater discontent with life (P < 0.05) than those with OJPP. Specific analysis of gastric complaints showed greatest dissatisfaction with gastrointestinal functions in patients after STG (P < 0.0004), less also after OJS compared with OJPP (P < 0.01).

CONCLUSIONS

Subtotal gastrectomy for gastric carcinoma has no advantages over total gastrectomy with oesophagojejunoplication and pouch as regards weight loss, gastrointestinal complaints, psychosocial stress and general contentment. The poor quality of life seems to have its functional correlate in increased intestino-oesophageal reflux with incompetent cardia and after Billroth II reconstruction.

摘要

目的

鉴于胃远端三分之一的T1和T2肠型胃癌,在淋巴结清扫范围和预后方面,胃次全切除术(STG)与全胃切除术相似,比较各种类型的胃次全切除术和全胃切除术后的生活质量。

患者与方法

通过标准化问卷对36例行胃次全切除术的患者(22例男性,14例女性;平均年龄63[27 - 79]岁)进行生活质量测量:一般身体不适(GPC);生活满意度(CL);心理社会压力(PSS)。将结果与之前58例行全胃切除术(46例男性,12例女性;平均年龄63.4[36 - 74]岁)并行食管空肠吻合术(OJS)(n = 29)或食管空肠吻合加袋状吻合术(OJPP)(n = 29)的患者的结果进行比较。

结果

OJPP术后患者的体重减轻与STG术后患者相比无显著差异,但OJS术后患者的体重减轻明显更高(13.5±8.6 kg;P < 0.0006)。与OJPP患者相比,STG患者有更多的一般不适(P < 0.05)和对生活更大的不满(P < 0.05)。对胃部不适的具体分析显示,STG术后患者对胃肠功能的不满最大(P < 0.0004),与OJPP相比,OJS术后患者的不满也较少(P < 0.01)。

结论

在体重减轻、胃肠不适、心理社会压力和总体满意度方面,胃癌胃次全切除术与全胃切除加食管空肠吻合加袋状吻合术相比没有优势。生活质量差似乎与其功能相关,即贲门功能不全和毕Ⅱ式重建后肠 - 食管反流增加。

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