Stefanov Yury, Salenko Veniamin, Glukhov Ivan
Engelhardt Institute of Molecular Biology; Russian Academy of Sciences; Moscow, Russia.
Mob Genet Elements. 2012 Jan 1;2(1):36-45. doi: 10.4161/mge.19234.
Retroelements with long-terminal repeats (LTRs) inhabit nearly all eukaryotic genomes. During the time of their rich evolutionary history they have developed highly diverse forms, ranging from ordinary retrotransposons to complex pathogenic retroviruses such as HIV-I. Errantiviruses are a group of insect endogenous LTR elements that share structural and functional features with vertebrate endogenous retroviruses. The errantiviruses illustrate one of the evolutionary strategies of retrotransposons to become infective, which together with their similarities to vertebrate retroviruses make them an attractive object of research promising to shed more light on the evolution of retroviruses.
具有长末端重复序列(LTRs)的逆转录元件几乎存在于所有真核生物基因组中。在其丰富的进化历史中,它们发展出了高度多样的形式,从普通的逆转录转座子到复杂的致病性逆转录病毒,如HIV-I。漫游病毒是一类昆虫内源性LTR元件,与脊椎动物内源性逆转录病毒具有结构和功能特征。漫游病毒说明了逆转录转座子成为感染性元件的一种进化策略,它们与脊椎动物逆转录病毒的相似性使其成为一个有吸引力的研究对象,有望为逆转录病毒的进化提供更多线索。