披着羊皮的狼：血小板衍生的“伪自我”损害 NK 细胞对癌细胞“丢失自我”的识别。
The wolf in sheep's clothing: Platelet-derived "pseudo self" impairs cancer cell "missing self" recognition by NK cells.
机构信息
Department of Hematology/Oncology; Eberhard Karls University; Tuebingen, Germany.
出版信息
Oncoimmunology. 2012 Jul 1;1(4):557-559. doi: 10.4161/onci.19367.
Abstract
Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce anti-tumor immunity and NK-based immunotherapy in cancer patients.
摘要
血小板减少症小鼠的转移受到强烈抑制。NK 细胞耗竭可逆转这种表型，表明血小板可能通过干扰 NK 细胞免疫监视来促进肿瘤的进展和转移。了解其潜在机制可能有助于我们增强癌症患者的抗肿瘤免疫和基于 NK 细胞的免疫治疗。
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