Chen Shih-Wei, Lai Jr-Jie, Chiang Chen-Li, Chen Cheng-Lung
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Rev Sci Instrum. 2012 Jun;83(6):064701. doi: 10.1063/1.4723814.
Magnetic hyperthermia using magnetic nanoparticles (MNPs) has attracted considerable attention as one of the promising tumor therapy. The study has been developed under single magnetic field. Recently, we found that the immobile MNP may generate more heat under two synchronous ac magnetic fields than traditional single and circular polarized fields based on model simulation result. According to this finding we constructed an orthogonal synchronized bi-directional field (OSB field). The system contained two LC resonant inverters (L: inductor, C: capacitor) and both vertical and transverse ac magnetic fields were generated by two Helmholtz coils. To reduce the interference, the axis directional of two coils were arranged orthogonally. The experiments showed that the heating ability of aggregated MNPs is greatly enhanced under this newly designed OSB field without increasing the strength of magnetic field. The OSB field system provides a promising way for future clinical hyperthermia.
使用磁性纳米颗粒（MNPs）的磁热疗作为一种很有前景的肿瘤治疗方法已引起了相当大的关注。该研究是在单磁场下开展的。最近，基于模型模拟结果我们发现，固定不动的MNP在两个同步交流磁场下可能比传统的单场和圆极化场产生更多热量。根据这一发现，我们构建了一个正交同步双向场（OSB场）。该系统包含两个LC谐振逆变器（L：电感器，C：电容器），垂直和横向交流磁场均由两个亥姆霍兹线圈产生。为减少干扰，两个线圈的轴向相互正交排列。实验表明，在这种新设计的OSB场下，聚集的MNPs的加热能力在不增加磁场强度的情况下得到了极大增强。OSB场系统为未来的临床热疗提供了一种很有前景的方法。
