Department of Pediatric Cardiology, Konya Training and Research Hospital, Konya, Turkey.
Platelets. 2013;24(5):378-82. doi: 10.3109/09537104.2012.701029. Epub 2012 Jul 3.
Acute rheumatic fever (ARF) is still an endemic disease, especially among school-aged children in developing countries. Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to investigate MPV in children with ARF. The study population consisted of 40 children with ARF (32 patients with carditis and 8 patients without carditis) and 40 healthy control subjects. White blood cell (WBC) and platelet counts were significantly higher and MPV values were significantly lower in patients with ARF during the acute stage when compared to controls. Erythrocyte sedimentation rate (ESR) and C-reactive protein values significantly decreased in patients with ARF after the treatment when compared to baseline, whereas MPV values increased. MPV values were negatively correlated with ESR and WBC, and platelet counts. In conclusion, during the acute stage of ARF, MPV values were lower when compared to controls.
急性风湿热（ARF）仍然是一种地方性疾病，特别是在发展中国家的学龄儿童中。平均血小板体积（MPV）通常用作血小板大小的衡量标准，可指示血小板生成和血小板活化的速度。我们旨在研究 ARF 患儿的 MPV。研究人群包括 40 例 ARF 患儿（32 例合并心炎，8 例无合并心炎）和 40 例健康对照者。与对照组相比，急性发作期 ARF 患儿的白细胞（WBC）和血小板计数明显升高，MPV 值明显降低。与基线相比，ARF 患儿经治疗后红细胞沉降率（ESR）和 C 反应蛋白值显著降低，而 MPV 值升高。MPV 值与 ESR 和 WBC 呈负相关，与血小板计数呈负相关。总之，与对照组相比，ARF 患儿在急性发作期的 MPV 值较低。
