Ozdemir Rahmi, Karadeniz Cem, Doksoz Onder, Celegen Mehmet, Yozgat Yılmaz, Guven Barıs, Meşe Timur, Unal Nurettin
Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11 Alsancak, Izmir, Turkey.
Pediatr Cardiol. 2014 Jan;35(1):53-6. doi: 10.1007/s00246-013-0738-9. Epub 2013 Jun 19.
Rheumatic fever (RF) is an inflammatory disease caused by autoimmune response to a preceding group A streptococcal infection. Mean platelet volume (MPV) reflects the platelet size and the rate of platelet production in bone marrow, and it may be used as an indicator of platelet activation and severity of inflammation. Fifty-three consecutive patients diagnosed with acute rheumatic carditis and 53 control subjects were enrolled into this study. Leukocyte and platelet counts were significantly higher in patients with acute carditis before treatment compared with controls, whereas MPV and platelet distribution width (PDW) values were not significantly different between groups. Platelet counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) values were decreased significantly in patients with RF after treatment. There was not a significant difference in terms of platelet count between the controls and the patient group after treatment. ESR was found to be correlated with CRP in patients before and after treatment. In conclusion, the results of our study showed that MPV and PDW levels do not change during acute rheumatic carditis before and after treatment.
风湿热（RF）是一种由对先前A组链球菌感染的自身免疫反应引起的炎症性疾病。平均血小板体积（MPV）反映血小板大小和骨髓中血小板生成速率，它可用作血小板活化和炎症严重程度的指标。本研究纳入了53例连续诊断为急性风湿性心脏炎的患者和53例对照受试者。治疗前，急性心脏炎患者的白细胞和血小板计数显著高于对照组，而两组间MPV和血小板分布宽度（PDW）值无显著差异。治疗后，RF患者的血小板计数、红细胞沉降率（ESR）和C反应蛋白（CRP）值显著降低。治疗后对照组与患者组之间的血小板计数无显著差异。治疗前后患者的ESR均与CRP相关。总之，我们的研究结果表明，急性风湿性心脏炎治疗前后MPV和PDW水平不变。
