Küçükbayrak Abdulkadir, Taş Tekin, Tosun Mehmet, Aktaş Gülali, Alçelik Aytekin, Necati Hakyemez Ismail, Koçoğlu Esra, Akdeniz Hayrettin
1Department of Infectious Diseases and Clinical Microbiology, 2Department of Medical Microbiology, 3Department of Biochemistry, 4Department of Internal Medicine; Abant Izzet Baysal University, School of Medicine, Bolu, Turkey.
Med Glas (Zenica). 2013 Feb;10(1):35-9.
To investigate links between platelet parameters mean platelet volume (MPV), platelet count (PC), platelet distribution width (PDW), platelet mass (PM) and brucella tube agglutination titers (BSTAT) in patients with brucellosis. Initially, PC, MPV, PM and PDW calculations were compared between periods before and after treatment. The correlation between inflammation markers (erythrocyte sedimentation rate, ESR, white blood cell count, WBC, and C reactive protein, CRP) and platelet parameters was subsequently investigated.
This self-controlled study included 40 patients who had positive BSTAT at least at a titer of 1/160. Platelet parameters and inflammation values (CRP, ESR) at the time of positive BSTAT at least at a titer of 1/160 (pre-treatment) were compared with control of the same parameters at the time when BSTAT became negative or when the titers reduced 4 folds (post-treatment).
Mean platelet volume values (7.90+1.96) were significantly elevated in post treatment period when compared to pre treatment (7.58+1.96), (p= 0.023). Post treatment CRP, ESR and PC were significantly reduced when compared to pretreatment values (p=0.000, p=0.000 and p=0.025, respectively). In the pretreatment period, a direct correlation between ESR and PC values (r=0.036, p=0.025), and inverse correlations between ESR with MPV (r=-0.337, p=0.038) was found. A dependent predictive factor in multivariate logistic regression analysis for BSTAT was not found.
We suggest that PC and MPV may be inflammatory markers in brucellosis.
研究布鲁氏菌病患者血小板参数平均血小板体积（MPV）、血小板计数（PC）、血小板分布宽度（PDW）、血小板质量（PM）与布鲁氏菌试管凝集效价（BSTAT）之间的联系。首先，比较治疗前后各时期的PC、MPV、PM和PDW计算值。随后研究炎症标志物（红细胞沉降率、ESR、白细胞计数、WBC和C反应蛋白、CRP）与血小板参数之间的相关性。
本自我对照研究纳入了40例BSTAT至少为1/160阳性的患者。将BSTAT至少为1/160阳性时（治疗前）的血小板参数和炎症值（CRP、ESR）与BSTAT转阴或效价降低4倍时（治疗后）相同参数的对照值进行比较。
与治疗前（7.58+1.96）相比，治疗后平均血小板体积值（7.90+1.96）显著升高，（p=0.023）。与治疗前值相比，治疗后CRP、ESR和PC显著降低（分别为p=0.000、p=0.000和p=0.025）。在治疗前期，发现ESR与PC值之间存在直接相关性（r=0.036，p=0.025），ESR与MPV之间存在负相关性（r=-0.337，p=0.038）。在多因素逻辑回归分析中未发现BSTAT的相关预测因素。
我们认为PC和MPV可能是布鲁氏菌病的炎症标志物。
