母亲血管紧张素Ⅱ受体1型（AGTR1）基因多态性与子痫前期的关联：一项系统评价和荟萃分析。
Association of maternal AGTR1 polymorphisms and preeclampsia: a systematic review and meta-analysis.
作者信息
Zhao Linlu, Dewan Andrew T, Bracken Michael B
机构信息
Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health , New Haven, CT 06510,USA.
出版信息
J Matern Fetal Neonatal Med. 2012 Dec;25(12):2676-80. doi: 10.3109/14767058.2012.708370. Epub 2012 Aug 3.
OBJECTIVE
Systematic review and meta-analysis to investigate the association between maternal AGTR1 gene single nucleotide polymorphisms (SNPs) and preeclampsia (PE).
METHODS
A systematic literature search was performed using PubMed, EMBASE, Scopus, and HuGE Literature Finder databases. The review was conducted according to PRISMA guidelines. Summary odds ratios (ORs) for the allelic and genotypic contrasts were calculated and compared to indicate the most appropriate genetic model for the polymorphism of interest. Among-study heterogeneity was assessed using the I(2) statistic and publication bias was evaluated visually using funnel plots.
RESULTS
Seven maternal SNPs investigated with PE were found, but only AGTR1 +1166A>C accumulated sufficient evidence for meta-analysis. Summary ORs calculated from eight studies (10 populations involving 845 PE cases and 1150 controls) did not reveal an association between the +1166A>C polymorphism and PE (allelic OR = 1.19, 95% CI: 0.96-1.47). No evidence of publication bias and among-study heterogeneity was detected.
CONCLUSIONS
meta-analysis findings did not support AGTR1 +1166A>C as a susceptibility locus for PE. Other AGTR1 SNPs require more study.
目的
进行系统评价和荟萃分析，以研究母亲血管紧张素Ⅱ受体1型（AGTR1）基因单核苷酸多态性（SNP）与子痫前期（PE）之间的关联。
方法
使用PubMed、EMBASE、Scopus和HuGE文献检索数据库进行系统的文献检索。该评价按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。计算并比较等位基因和基因型对比的汇总比值比（OR），以表明所关注多态性的最合适遗传模型。使用I²统计量评估研究间异质性，并使用漏斗图直观评估发表偏倚。
结果
发现7个与子痫前期相关的母亲SNP，但只有AGTR1 +1166A>C积累了足够的荟萃分析证据。从8项研究（涉及10个群体，包括845例子痫前期病例和1150例对照）计算得出的汇总OR未显示+1166A>C多态性与子痫前期之间存在关联（等位基因OR = 1.19，95%CI：0.96 - 1.47）。未检测到发表偏倚和研究间异质性的证据。
结论
荟萃分析结果不支持AGTR1 +1166A>C作为子痫前期的易感基因座。其他AGTR1 SNP需要更多研究。
Zotero 插件