Suboticanec K, Folnegović-Smalc V, Korbar M, Mestrović B, Buzina R
School of Medicine, University of Zagreb, Yugoslavia.
Biol Psychiatry. 1990 Dec 1;28(11):959-66. doi: 10.1016/0006-3223(90)90061-6.
Schizophrenic patients on the same hospital diet as control group subjects had significantly lower levels of fasting plasma vitamin C (p less than 0.05) and 6-hr urinary vitamin C excretion after an ascorbic acid load test (p less than 0.01). After administration of 70 mg of ascorbic acid for 4 weeks there was no longer any difference in plasma vitamin C levels between schizophrenics and control group subjects, but the urinary vitamin C excretion after the vitamin C loading test remained significantly lower in schizophrenics (p less than 0.05). The administration of 1 g ascorbic acid for 4 weeks, in addition to eliminating differences in the plasma vitamin C level, also increased the urinary vitamin C excretion of schizophrenic patients to the level of the control group subjects. The results of this study are in agreement with the hypothesis that schizophrenic patients require higher levels of vitamin C than the suggested optimal ascorbic acid requirement for healthy humans.
与对照组受试者食用相同医院饮食的精神分裂症患者，空腹血浆维生素C水平显著较低（p<0.05），在进行抗坏血酸负荷试验后，6小时尿维生素C排泄量也显著较低（p<0.01）。给予70毫克抗坏血酸4周后，精神分裂症患者与对照组受试者的血浆维生素C水平不再有差异，但在维生素C负荷试验后，精神分裂症患者的尿维生素C排泄量仍显著较低（p<0.05）。给予1克抗坏血酸4周，除了消除血浆维生素C水平的差异外，还将精神分裂症患者的尿维生素C排泄量提高到了对照组受试者的水平。本研究结果与以下假设一致，即精神分裂症患者比健康人建议的最佳抗坏血酸需求量需要更高水平的维生素C。
